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Metabolism of Various Arsenic Compounds upon Ingestion of Brown Algae by Warm-Blooded Organisms (Review)

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Pharmaceutical Chemistry Journal Aims and scope

Literature data on the metabolism in warm-blooded organisms of inorganic and organic arsenic compounds contained in brown algae are summarized. Their final metabolites are shown to be low-toxic compounds of pentavalent arsenic that are excreted from the body during short-term intake of brown algae but accumulate in it during long-term consumption. Intermediate metabolites (including organic forms) contain toxic trivalent arsenic compounds. Acertain amount of toxic trivalent arsenic compounds can be present in the gastrointestinal tract because of the reversible oxidation of trivalent arsenic compounds to pentavalent arsenic compounds. These compounds pose a risk to human health when brown algae are regularly ingested as foods, dietary supplements, and herbal medicines. Regulation of the total arsenic content in medicinal herbal raw materials and medicinal herbal preparations is shown to be preferable to regulation of the content of inorganic arsenic forms.

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  1. Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of Russia, 8/2 Petrovskii Blvd., Moscow, 127051, Russia

    V. M. Shchukin, A. A. Erina, N. E. Kuz’mina & N. O. Bunyatyan

  2. Pyatigorsk Medical and Pharmaceutical Institute, Ministry of Health of Russia, 11 Kalinina Prosp., Pyatigorsk, 357500, Russia

    I. P. Remezova

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  1. V. M. Shchukin
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  2. A. A. Erina
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Correspondence to V. M. Shchukin.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 1, pp. 37 – 42, January, 2023.

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Shchukin, V.M., Erina, A.A., Kuz’mina, N.E. et al. Metabolism of Various Arsenic Compounds upon Ingestion of Brown Algae by Warm-Blooded Organisms (Review). Pharm Chem J 57, 83–88 (2023). https://doi.org/10.1007/s11094-023-02854-9

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