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Synthesis and Biological Activity of 4-(3,4-Dibromothiophenecarbonyl)-2,6,8,10,12-Pentaacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane: A New Non-Narcotic Analgesic of the Hexaazaisowurtzitane Class

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A method for production of a promising non-narcotic analgesic of the hexaazaisowurtzitane class is developed. Data on the physicochemical characteristics and conditions for obtaining the target substance are presented. The effectiveness of the resulting agent is shown in several animal models. A pronounced analgesic effect of the newly synthesized compound 4-(3,4-dibromothiophenecarbonyl)-2,6,8,10,12-pentaacetyl-2,4,6,8,10,12-hexaazaisowurtzitane comparable or even superior to that of tramadol was revealed.

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Authors and Affiliations

  1. Institute for Problems of Chemical and Energetic Technologies, Siberian Branch, Russian Academy of Sciences (IPCET SB RAS), 1 Sotsialisticheskaya St., Biysk, 659322, Russia

    V. V. Eremina, D. A. Kulagina, O. V. Baibakova & S. V. Sysolyatin

  2. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, 3 Lenina Prosp., Tomsk, 634028, Russia

    S. G. Krylova, E. A. Kiseleva, T. N. Povetyeva, E. P. Zueva, N. I. Suslov, E. N. Amosova, T. G. Razina, O. Yu. Rybalkina, Yu. V. Nesterova, O. G. Afanasyeva, P. V. Kulpin & V. V. Zhdanov

Authors
  1. V. V. Eremina
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  2. D. A. Kulagina
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  3. S. G. Krylova
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  4. E. A. Kiseleva
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  5. T. N. Povetyeva
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  6. E. P. Zueva
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  7. N. I. Suslov
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  8. E. N. Amosova
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  9. T. G. Razina
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  10. O. Yu. Rybalkina
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  11. Yu. V. Nesterova
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  12. O. G. Afanasyeva
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  13. P. V. Kulpin
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  14. O. V. Baibakova
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  15. S. V. Sysolyatin
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  16. V. V. Zhdanov
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Corresponding author

Correspondence to D. A. Kulagina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 1, pp. 13 – 18, January, 2023.

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Eremina, V.V., Kulagina, D.A., Krylova, S.G. et al. Synthesis and Biological Activity of 4-(3,4-Dibromothiophenecarbonyl)-2,6,8,10,12-Pentaacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane: A New Non-Narcotic Analgesic of the Hexaazaisowurtzitane Class. Pharm Chem J 57, 40–45 (2023). https://doi.org/10.1007/s11094-023-02848-7

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  • DOI: https://doi.org/10.1007/s11094-023-02848-7

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