Skip to main content
SpringerLink
Log in

Evaluation of Prebiotic Effectiveness of Thermopsis alterniflora Flavonoids and Isoflavonoids in Experiments In Vivo

  • MEDICINAL PLANTS
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

The prebiotic properties of the flavonoids and isoflavonoids orobol, formononetin, genistin, luteolin, and chrysoeriol isolated from Thermopsis alterniflora Regel et Schmalh. were studied in vivo on a model of experimental antibiotic-associated dysbiosis caused by gentamicin in mice. The flavone luteolin and isoflavone orobol, which significantly stimulated the growth and development of the main representatives of the intestinal microbiome, i.e., bifidobacteria and lactobacilli, and suppressed the phenomenon of dysbiosis, were found to have the most pronounced prebiotic effects. The experimental data were indicative of the potential of using flavonoids obtained from T. alterniflora, which provide a safe and favorable effect on the normal microbiome of the gastrointestinal tract and well-being of animals, as effective prebiotic agents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. Duda-Chodak, T. Tarko, P. Satora, et al., Eur. J. Nutr., 54, 325 – 341 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. A. Braune and M. Blaut, Gut Microbes, 7(3), 216 – 234 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. B. Zhu, X. Wang, and L. Li, Protein Cell, 1(8), 718 – 725 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  4. J. M. Landete, Crit. Rev. Food Sci. Nutr., 52(10), 936 – 948 (2012).

    Article  CAS  PubMed  Google Scholar 

  5. T. Ozdal, D. A. Sela, J. Xiao, et al., Nutrients, 8, 78 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  6. F. Rafii, Metabolites, 5, 56 – 73 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Ya. F. Zverev, Obz. Klin. Farmakol. Lek. Ter., 15(2), 4 – 11 (2017).

    Article  Google Scholar 

  8. N. S. Kattaev and G. K. Nikonov, Chem. Nat. Compd., 8, 618 (1972).

    Article  Google Scholar 

  9. N. S. Kattaev and G. K. Nikonov, Chem. Nat. Compd., 9, 108 – 109 (1973).

    Article  Google Scholar 

  10. N. S. Kattaev and G. K. Nikonov, Chem. Nat. Compd., 11, 157 – 159 (1975).

    Article  Google Scholar 

  11. M. P. Yuldashev, E. Kh. Batirov, A. D. Vdovin, et al., Chem. Nat. Compd., 25, 303 – 308 (1989).

    Article  Google Scholar 

  12. M. P. Yuldashev, E. Kh. Batirov, and V. M. Malikov, Chem. Nat. Compd., 26, 465 – 466 (1990).

    Article  Google Scholar 

  13. T. J. Mabry, K. R. Markham, and M. B. Thomas, The Systematic Identification of Flavonoids, Springer-Verlag, Berlin (1970).

    Book  Google Scholar 

  14. K. R. Markham, Techniques of Flavonoid Identification, Academic Press, London (1982).

    Google Scholar 

  15. https: // www.vidal.ru / drugs / lactulose-1?ysclid=l7yx49tupk551866552.

  16. I. Yu. Chicherin, I. V. Darmov, I. P. Pogorel′skii, et al., Zh. Infektol., 4(1), 75 – 80 (2012).

    Google Scholar 

  17. V. N. Syrov, M. P. Yuldashev, M. I. Mamutov, et al., Pharm. Chem. J., 35(1), 30 – 34 (2001).

    Article  CAS  Google Scholar 

  18. I. Yu. Chicherin, I. V. Darmov, I. P. Pogorel′skii, et al., Kishechnaya Mikroflora, No. 2, 36 – 41 (2013).

    Google Scholar 

  19. V. M. Bondarenko and V. G. Likhoded, Microbiological Diagnosis of Intestinal Dysbacteriosis [in Russian], Moscow (2007).

  20. J. Hoult, N. Krieg, and P. Snit, Bergey′s Manual of Systematic Bacteriology [Russian translation], Vol. 2, Mir, Moscow (1997).

    Google Scholar 

  21. I. P. Ashmarin and A. A. Vorob′ev, Statistical Methods in Microbiological Research [in Russian], Medgiz, Leningrad (1962).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Acad. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 77 Mirzo Ulugbek St, 100170, Tashkent, Uzbekistan

    Zh.I. Islamova & E. Kh. Botirov

  2. Republican Scientific and Practical Medical Center of Epidemiology, Microbiology, Infections and Parasitic Diseases, 2 Zakovat St, 100151, Tashkent, Uzbekistan

    G. Kh. Ahmedova

Authors
  1. Zh.I. Islamova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Kh. Botirov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Kh. Ahmedova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zh.I. Islamova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 11, pp. 28 – 32, November, 2022.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Islamova, Z., Botirov, E.K. & Ahmedova, G.K. Evaluation of Prebiotic Effectiveness of Thermopsis alterniflora Flavonoids and Isoflavonoids in Experiments In Vivo. Pharm Chem J 56, 1457–1461 (2023). https://doi.org/10.1007/s11094-023-02813-4

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-023-02813-4

Keywords

Search

Navigation