New palladium-containing polymer catalysts for hydrogenating amination of ethyl 2-oxo-4-phenylbutanoate with α-alanyl-α-proline dipeptide were obtained. The optimal improved scheme for catalytic synthesis of enalapril under mild conditions is proposed based on the obtained empirical data. The catalytic properties of the new palladium-containing polymer catalysts of this reaction were compared with the classical heterogeneous palladium hydrogenation catalysts Pd/C and Pd/CaCO3. The selectivity and stability of the new palladium-containing polymer catalysts are found to significantly exceed those of their heterogeneous analogs.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 10, pp. 48 – 51, October, 2022.
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Abdullaev, M.G. New Palladium-Containing Polymer Catalysts for the Synthesis of Enalapril. Pharm Chem J 56, 1383–1386 (2023). https://doi.org/10.1007/s11094-023-02801-8
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DOI: https://doi.org/10.1007/s11094-023-02801-8