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Inclusion Complex of 11-deoxymisoprostol and Glycyrrhizic Acid with Improved Anti-Ulcer Activity

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A 1:4 inclusion complex of 11-deoxymisoprostol (II) with glycyrrhizic acid (complex III) was synthesized and exhibited high anti-ulcer activity in experimental models of gastric mucosal ulcers (GMUs) inWistar rats induced by indomethacin and diclofenac. Complex III at a dose of 1 mg/kg (0.1 mg of II) reduced the number of indomethacin gastric ulcers by 46.4% (p < 0.012) as compared with the control group and by 39.2% as compared with II at the same dose. The anti-ulcer activity of complex III at a dose of 1 mg/kg was 5.8 times higher than that of the initial prostaglandin at an equivalent dose (0.1 mg/kg) in a model of gastric ulcers caused by diclofenac.

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ACKNOWLEDGMENTS

The work was performed on State Task topics 1021062311395-6-1.4.1, AAAA-A17-117011910032-4, AAAA-A20-120012090021-4, and 1021062311386-8-1.4.1.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Scientific Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, Bashkortostan, 450054, Russia

    L. A. Baltina, N. A. Ivanova, T. A. Sapozhnikova, S. F. Gabdrakhmanova, R. Yu. Khisamutdinova, N. S. Makara, T. R. Nugumanov, S. F. Petrova & M. S. Miftakhov

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  1. L. A. Baltina
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  2. N. A. Ivanova
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Correspondence to L. A. Baltina.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 5, pp. 34 – 39, May, 2022.

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Baltina, L.A., Ivanova, N.A., Sapozhnikova, T.A. et al. Inclusion Complex of 11-deoxymisoprostol and Glycyrrhizic Acid with Improved Anti-Ulcer Activity. Pharm Chem J 56, 607–613 (2022). https://doi.org/10.1007/s11094-022-02684-1

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