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Evaluation of the Pharmacotherapeutic Efficacy of Cycloartane Glycosides in Comparison to Lovastatin in Rabbits with Experimental Atherosclerosis

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Pharmaceutical Chemistry Journal Aims and scope

The cycloartane glycosides cyclocarposide and cyclosieversioside F prevent an increase in the blood serum contents of cholesterol, triglycerides, and total fraction of pre-β- and β-lipoproteins in rabbits with atherosclerosis. They increase the ratio of α-cholesterol to total cholesterol and reduce the calculated coefficient of atherogenicity and the ratio of the total fraction of pre-β- and β-lipoproteins to α-cholesterol. In addition, the cycloartane glycosides restore the activity of antioxidant and NO-ergic systems in the heart muscle that is reduced in rabbits with atherosclerosis. The investigated cycloartane glycosides (especially cyclocarposide) had antiatherosclerotic action inferior to that of lovastatin, a drug from the statin group, and had certain advantages over lovastatin with respect to their effects on the antioxidant and NO-ergic systems.

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Authors and Affiliations

  1. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 77 Mirzo Ulugbeka St., Tashkent, Uzbekistan, 100170

    V. N. Syrov, T. N. Kaipnazarov, A. V. Tsaruk, Zh. I. Islamova, G. A. Shakhmurova, F. R. Egamova, N. Sh. Ramazanov & Z. A. Khushbaktova

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  1. V. N. Syrov
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  2. T. N. Kaipnazarov
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  3. A. V. Tsaruk
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  4. Zh. I. Islamova
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  5. G. A. Shakhmurova
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  6. F. R. Egamova
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  7. N. Sh. Ramazanov
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  8. Z. A. Khushbaktova
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Correspondence to G. A. Shakhmurova.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 5, pp. 14 – 18, May, 2022.

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Syrov, V.N., Kaipnazarov, T.N., Tsaruk, A.V. et al. Evaluation of the Pharmacotherapeutic Efficacy of Cycloartane Glycosides in Comparison to Lovastatin in Rabbits with Experimental Atherosclerosis. Pharm Chem J 56, 587–591 (2022). https://doi.org/10.1007/s11094-022-02680-5

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  • DOI: https://doi.org/10.1007/s11094-022-02680-5

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