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Synthesis, DNA Binding and Cytotoxic Activity of Newcopper(II) Complexes of Trisubstituted Imidazoles

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Pharmaceutical Chemistry Journal Aims and scope

This study was aimed to synthesize and characterize two new copper(II) complexes, [Cu(phen)(Br-impi)]2+ (1) and [Cu(phen)(M-impi)]2+ (2) (where phen is 1,10-phenanthroline; Br-impi is 2-(2-(4-bromophenyl)-4- (pyridin-2-yl)-4,5-dihydro-1H-imidazol-5-yl)pyridine, andM-impi is 2-(2-(4-methoxyphenyl)-4-(pyridin- 2-yl)-4,5-dihydro-1H-imidazol-5-yl)pyridine), and to study their DNAbinding activity and cytotoxic activity. The interaction of complexes with ds-DNA has been investigated by spectroscopic methods, viscosity measurements, and agarose gel electrophoresis. The results indicate that complex 1 can bind to ds-DNA better than doescomplex 2 with binding constants 1.9 × 105M-1 and 3.9 × 104M-1, respectively.According to the UV titration method, complex 1 is capable of extractingethidium bromide molecules from DNA base pairs at lower concentrations than complex 2. In oxidative medium, both complexes produce complete degradationof plasmid DNA. Thecomplexes were screened against five human cell lines, namely A 549, PC-3, BEAS-2B, HCT-116 and MDZ-MB-231, and it was found that copper(II) complexes of trisubstituted imidazoleexhibited cytotoxic activity.

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Conflict of Interest

The authors declare that theyhave no conflictstoffinterest

Funding

The authors thank Zonguldak Bulent Ecevit University for sponsoring this project with a grant number 2020-72118496-02.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Arts and Sciences, Bulent Ecevit University, 67100, Zonguldak, Turkey

    Zuhal Gerçek & Ufuk Yıldız

  2. Faculty of Health Sciences, Istinye University, 34010, Istanbul, Turkey

    Engin Ulukaya & R. Okan Akar

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  1. Zuhal Gerçek
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  2. Ufuk Yıldız
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  3. Engin Ulukaya
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  4. R. Okan Akar
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Correspondence to Zuhal Gerçek.

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Gerçek, Z., Yıldız, U., Ulukaya, E. et al. Synthesis, DNA Binding and Cytotoxic Activity of Newcopper(II) Complexes of Trisubstituted Imidazoles. Pharm Chem J 55, 1320–1328 (2022). https://doi.org/10.1007/s11094-022-02578-2

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  • DOI: https://doi.org/10.1007/s11094-022-02578-2

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