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Evaluation of the Compatibility of Moxifloxacin with Selected Excipients Used in the Formulation of Nanopharmaceuticals

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Pharmaceutical Chemistry Journal Aims and scope

Drug excipients are chemical substances that can interact with each other and with APIs, thus affecting characteristics of the final dosage form. Selection of excipients for the preparation of nanopharmaceuticals is very critical because there are more chances of physical and chemical interactions. The current study was carried out to investigate the possibility of any chemical or physical interaction between moxifloxacin hydrochloride and selected excipients (polymers and surfactants) used in the formulation of polymeric nanoparticles. Samples were prepared using the binary mixture approach and then stored under stress conditions (40 ± 2°C and 75 ± 5% RH) for 90 days. The compatibility studies were carried out by visual observations, HPLC-UV, XRD and FTIR analysis. No visual changes were observed in any of the samples, drug content of the samples was within the range of 98 – 100.37%. FTIR spectra remained unaffected, and all the characteristic XRD peaks were present which indicated that the drug was compatible with the excipients used. The results of this investigation confirm that moxifloxacin hydrochloride is compatible with the selected excipients, and the polymeric drug nanoparticles can be formulated without any stability issues.

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Acknowledgments

We express our gratitude to the Department of Pharmacy, University of Peshawar, Peshawar and Ferozsons Laboratories Ltd. (Pakistan) for providing research facilities.

Conflict of Interest Statement

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Pharmacy, University of Peshawar, Peshawar, Pakistan

    Fahim Ullah Khan, Fazli Nasir & Muhammad Hassan

  2. Department of Pharmacy, City University of Science and Information Technology Peshawar, Peshawar, Pakistan

    Fahim Ullah Khan

  3. Department of Pharmacy, Kohat University of Science and Technology (KUST), Kohat, Pakistan

    Amjad Khan

  4. Department of Pharmacy, Abasyn University Peshawar, Peshawar, Pakistan

    Aman Ullah & Fazle Rabbi

  5. Department of Pharmacy, Sarhad University of Science and Technology (SUIT) Peshawar, Peshawar, Pakistan

    Naila Shahbaz

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  1. Fahim Ullah Khan
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  2. Fazli Nasir
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  3. Muhammad Hassan
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  4. Amjad Khan
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  5. Aman Ullah
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  7. Naila Shahbaz
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Correspondence to Fahim Ullah Khan.

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Khan, F.U., Nasir, F., Hassan, M. et al. Evaluation of the Compatibility of Moxifloxacin with Selected Excipients Used in the Formulation of Nanopharmaceuticals. Pharm Chem J 55, 1184–1189 (2022). https://doi.org/10.1007/s11094-022-02556-8

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  • DOI: https://doi.org/10.1007/s11094-022-02556-8

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