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Doxorubicin Release from Bovine Serum Albumin Microparticles

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Pharmaceutical Chemistry Journal Aims and scope

Doxorubicin (Dox) is an anthracycline antibiotic and highly potent anticancer drug. However, its utility is often limited by severe side effects such as irreversible cardiotoxicity and reversible nephrotoxicity. In recent years, biopolymeric carriers have been used to overcome the disadvantages of conventional drug delivery systems. In this work, bovine serum albumin (BSA) microparticles were prepared and studied as natural biopolymeric carrier for anticancer agent release. The resulting microparticles were examined for entrapment efficiency and in vitro drug release profile. The entrapment efficiency of prepared BSA microparticles was 75%. Dox loaded BSA microparticles showed good in vitro release profile with the initial burst followed by slower and controlled release of the drug up to 96 h (4 days). The microparticles were evaluated against human liver cancer A549 cells (non-small-cell lung cancer cell line) and HeLa cells (cervical cancer cell line) by MTT reduction assay. The results showed that unloaded microparticles produced very low cytotoxic effects on both cancer cells at all incubation times. Drug loaded microparticles showed lower cell viability of HeLa cells in comparison with A549 cells. It is believed that the obtained results will contribute to the development of new drug delivery systems for cancer treatment.

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CONFLICT OF INTEREST

The authors declare that they have no conflicts of interest.

Funding

This work has been granted by the Muğla Sıtkı Koçman University Research Projects Coordination Office through Project Grant Number 18/045.

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Authors and Affiliations

  1. Muğla Sıtkı Koçman University Molecular Biology and Genetics Department, Mugla, Turkey

    Aydan Gülsu, Mutlu Can Aslanpay & Mehlika Alper

  2. Muğla Sıtkı Koçman University, Biology Department, Mugla, Turkey

    Hatice Güneş

Authors
  1. Aydan Gülsu
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  2. Mutlu Can Aslanpay
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  3. Mehlika Alper
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  4. Hatice Güneş
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Correspondence to Aydan Gülsu.

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Gülsu, A., Aslanpay, M.C., Alper, M. et al. Doxorubicin Release from Bovine Serum Albumin Microparticles. Pharm Chem J 55, 1157–1162 (2022). https://doi.org/10.1007/s11094-022-02552-y

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  • DOI: https://doi.org/10.1007/s11094-022-02552-y

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