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Technology for Obtaining a Substance Based on Flavonoids of the Aerial Part of Glycyrrhiza glabra

  • MEDICINAL PLANTS
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Pharmaceutical Chemistry Journal Aims and scope

A method for the purification of flavonoids isolated from the aerial part of Glycyrrhiza glabra L. was developed. It was established that total flavonoids should be isolated from a concentrated extract diluted with water using CHCl3 at least six times; from the CHCl3 extract, using 5% aqueous Na2CO3 solution at least eight times. Neutralization of the soda extract to pH 6.5 – 7 with 5% HCl solution was proposed. The optimum parameters for precipitation of total flavonoids were found to be triple reprecipitation of technical glacembrin with 60% EtOH. Technology for obtaining glacembrin substance based on flavonoids of the aerial part of G. glabra that possessed anti-inflammatory, antihypoxic, and analgesic activity was developed based on the research results. A spectrophotometric method for quantitative determination at 292 nm of total flavonoids recalculated as pinocembrin was proposed.

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Authors and Affiliations

  1. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 77 Mirzo Ulugbeka Blvd., Tashkent, Uzbekistan, 100170

    B. A. Abdurakhmanov, G. B. Sotimov, R. M. Khalilov & A. U. Mamatkhanov

Authors
  1. B. A. Abdurakhmanov
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  2. G. B. Sotimov
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  3. R. M. Khalilov
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  4. A. U. Mamatkhanov
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Correspondence to B. A. Abdurakhmanov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 10, pp. 18 – 22, October, 2021.

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Abdurakhmanov, B.A., Sotimov, G.B., Khalilov, R.M. et al. Technology for Obtaining a Substance Based on Flavonoids of the Aerial Part of Glycyrrhiza glabra. Pharm Chem J 55, 1057–1061 (2022). https://doi.org/10.1007/s11094-021-02537-3

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  • DOI: https://doi.org/10.1007/s11094-021-02537-3

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