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Viability of Tumor Cells (K562, Hep-2, HeLa) and Rat Fibroblasts in the Presence of Pterostilbene and Extracts of Licorice Root and Andrographis Paniculata

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Pharmaceutical Chemistry Journal Aims and scope

Results from in vitro studies of the effect of pterostilbene, licorice root extract, and Andrographis paniculata extract on the viability of rat fibroblast and tumor-cell cultures (K562, Hep-2, HeLa) are reported. The selectivity index of pterostilbene (SI = 12.8 – 2.34) indicates the presence of selective cytotoxicity against tumor cells that decreases in the order Hep-2 > K562 ≥ HeLa. Licorice root extract at a concentration of 0.00025 – 0.5 mg/mL showed no noticeable cytotoxicity against normal and tumor cells. The extract of A. paniculata suppressed the viability of human chronic myelogenous leukemia cells at a concentration of 0.2 mg/mL and of all studied normal and tumor cells at a concentration of 2 mg/mL without selectivity with respect to all studied tumor cells.

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Authors and Affiliations

  1. V. I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 19 Kosygina St, Moscow, 119991, Russia

    S. U. Shaikhina

  2. Ferran Research Center, Skolkovo Innovation Center, 42/1 Bol’shoi Blvd, Moscow, 121205, Russia

    S. U. Shaikhina & I. A. Gudovshchikov

  3. N. I. Pirogov Russian National Research Medical University, 1 Ostrovityanova St, Moscow, 117997, Russia

    A. V. Semeikin & N. L. Shimanovsky

Authors
  1. S. U. Shaikhina
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  2. A. V. Semeikin
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  3. I. A. Gudovshchikov
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  4. N. L. Shimanovsky
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Correspondence to S. U. Shaikhina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 9, pp. 24 – 28, September, 2021.

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Shaikhina, S.U., Semeikin, A.V., Gudovshchikov, I.A. et al. Viability of Tumor Cells (K562, Hep-2, HeLa) and Rat Fibroblasts in the Presence of Pterostilbene and Extracts of Licorice Root and Andrographis Paniculata. Pharm Chem J 55, 876–880 (2021). https://doi.org/10.1007/s11094-021-02511-z

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  • DOI: https://doi.org/10.1007/s11094-021-02511-z

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