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Spectrophotometric Method for the Simultaneous Analysis of Diclofenac Sodium and Lidocaine Hydrochloride in Bulk and Dosage Forms

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Pharmaceutical Chemistry Journal Aims and scope

Multicomponent analysis using overlapped spectra presents a great challenge in pharmaceutical quality control analysis. The present study was aimed to develop a simple and accurate UV spectrophotometric method for the determination of diclofenac sodium in the presence of lidocaine hydrochloride in an injectable dosage form. The proposed method is based on the simultaneous analysis of diclofenac sodium and lidocaine hydrochloride using two wavelengths (276 nm and 235 nm). Method validation was conducted in accordance with the ICH guidelines. The Beer-Lambert law was obeyed in a concentration range of 6 – 24 and 1.6 – 6.4 μg/mL for diclofenac sodium and lidocaine hydrochloride, respectively, with correlation coefficient not less than 0.996. It proved to be a precise method (RSD% < 3%, n = 6) with good recovery results, which reflects the freedom of interference with lidocaine and other excipients. Thus, the developed method has proved to be accurate and valid for the simultaneous analysis of diclofenac sodium and lidocaine hydrochloride.

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Acknowledgments

The authors are thankful for the local factories for providing the reference standards of the drugs under study.

Conflict of Interest

The authors declare that they have no conflict of interest.

Funding

Authors did not receive any financial assistance and the research was self-funded.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ribat National University, Ribat, Khartoum, Sudan

    Randa Mukkawi

  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, P. O. Box 1996, Khartoum, Sudan

    Shaza Shantier & E. A. Gadkariem

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  1. Randa Mukkawi
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  2. Shaza Shantier
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  3. E. A. Gadkariem
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Correspondence to Shaza Shantier.

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Mukkawi, R., Shantier, S. & Gadkariem, E.A. Spectrophotometric Method for the Simultaneous Analysis of Diclofenac Sodium and Lidocaine Hydrochloride in Bulk and Dosage Forms. Pharm Chem J 55, 831–834 (2021). https://doi.org/10.1007/s11094-021-02503-z

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  • DOI: https://doi.org/10.1007/s11094-021-02503-z

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