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Synthesis and Anti-Inflammatory Activity of N,6-Diaryl-4-Methyl-2-Thioxo-1,2,3,6-Tetrahydropyrimidine-5-Carboxamides

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Pharmaceutical Chemistry Journal Aims and scope

Previously unreported N,6-Diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides were synthesized by reacting acetoacetanilides with a mixture of an aromatic aldehyde and thiourea. The anti-inflammatory activity of the series of synthesized compounds was assessed. The anti-inflammatory activities of 4-methyl-N,6-diphenyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide and 4-methyl-N-phenyl-6-(2-chlorophenyl)-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide, which inhibited the inflammation reaction in a rat-paw edema model by 79.54 and 79.84%, respectively, were statistically significantly greater than that of nimesulide (55.74%).

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, 2 Polevaya St., Perm, 614990, Russia

    N. A. Buzmakova, I. P. Rudakova & T. M. Zamaraeva

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  1. N. A. Buzmakova
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  2. I. P. Rudakova
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  3. T. M. Zamaraeva
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Correspondence to N. A. Buzmakova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 8, pp. 21 – 24, August, 2021.

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Buzmakova, N.A., Rudakova, I.P. & Zamaraeva, T.M. Synthesis and Anti-Inflammatory Activity of N,6-Diaryl-4-Methyl-2-Thioxo-1,2,3,6-Tetrahydropyrimidine-5-Carboxamides. Pharm Chem J 55, 775–777 (2021). https://doi.org/10.1007/s11094-021-02492-z

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  • DOI: https://doi.org/10.1007/s11094-021-02492-z

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