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Photogenerated Iodine for Determination of Active Pharmaceutical Ingredients in Tetralgin Drug

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Pharmaceutical Chemistry Journal Aims and scope

A method for accelerated determination of active pharmaceutical ingredients (APIs) in Tetralgin combined preparation was developed based on preliminary extraction separation of the components followed by preparation of their aqueous extracts and voltammetric titration by a solution of photogenerated iodine obtained via irradiation of an auxiliary solution containing potassium iodide, a mixture of sensitizers (sodium eosinate:fluorescein:auramine, 1:1:1 mole ratio), and acetate buffer (pH 5.6). Extraction (CHCl3) separation of the drug components allowed extraction from a model solution of up to 97% caffeine (pH 11.0 – 12.0) and 98% phenobarbital (pH 4.0 – 5.0). The found contents of Tetralgin APIs were within the range recommended by GPM 1.4.2.0009.15 so that the quality of the drug met GMP standards.

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Authors and Affiliations

  1. Chuvash State University, 15 Moskovskii Prosp., Cheboksary, Chuvash Republic, 428003, Russia

    E. V. Turusova & O. E. Nasakin

Authors
  1. E. V. Turusova
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  2. O. E. Nasakin
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Correspondence to E. V. Turusova.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 7, pp. 55 – 59, July, 2021.

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Turusova, E.V., Nasakin, O.E. Photogenerated Iodine for Determination of Active Pharmaceutical Ingredients in Tetralgin Drug. Pharm Chem J 55, 740–744 (2021). https://doi.org/10.1007/s11094-021-02486-x

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  • DOI: https://doi.org/10.1007/s11094-021-02486-x

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