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Synthesis and Pharmacological Properties of the Azo-Conjugate of Erythropoietin β with Poly(Ethylene Glycol)

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

A conjugate of erythropoietin β with 30 kDa linear methoxy poly(ethylene glycol) characterized by the presence of an azo spacer between the protein fragment and poly(ethylene glycol) was developed for import-substitution of Mircera drug in the Russian Federation. The erythropoietic activity of the synthesized conjugate was determined. Its pharmacokinetics in CBA mice were found to be comparable to those of Mircera. The bioequivalence of the proposed azo conjugate and Mircera was established based on the calculated drug pharmacokinetic parameters in mice.

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Authors and Affiliations

  1. FORT LLC, Okskoe, Ryazan Region, 390540, Russia

    S. V. Sheremet’ev, D. V. Lonshakov, E. M. Belosludtseva, A. V. Sidorova & A. V. Kalinskii

  2. I. I. Mechnikov Institute of Vaccines and Sera, 5a Malyi Kazennyi Pereulok, Moscow, 105064, Russia

    O. V. Borisova

Authors
  1. S. V. Sheremet’ev
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  2. D. V. Lonshakov
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  3. E. M. Belosludtseva
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  4. O. V. Borisova
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  5. A. V. Sidorova
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  6. A. V. Kalinskii
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Corresponding author

Correspondence to D. V. Lonshakov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 7, pp. 30 – 37, July, 2021.

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Sheremet’ev, S.V., Lonshakov, D.V., Belosludtseva, E.M. et al. Synthesis and Pharmacological Properties of the Azo-Conjugate of Erythropoietin β with Poly(Ethylene Glycol). Pharm Chem J 55, 698–705 (2021). https://doi.org/10.1007/s11094-021-02480-3

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  • DOI: https://doi.org/10.1007/s11094-021-02480-3

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