The lipid-transfer protein Ns-LTP1 was isolated from Nigella sativa seeds using a complex of chromatographic methods. Its effect on the course of experimental ulcerative colitis in rats was studied. The effect of biologically active peptides classified as lipid-transfer proteins on the course of experimental ulcerative colitis in rats was compared to that of sulfasalazine. It was found that lipid-transfer protein Ns-LTP1 had pronounced antiulcer, anti-inflammatory, and antipyretic effects on a model of acute experimental colitis in rats and helped to restore body mass and temperature of the animals. This indicated it is promising for creation of a composition based on lipid-transfer protein Ns-LTP1 for therapy of inflammatory diseases of the colon, namely nonspecific ulcerative colitis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. E. Baksht, E. I. Beloborodova, V. A. Burkovskaya, et al., Sib. Vestn. Psikhiatr. Narkol., 6, 43 – 46 (2013).
J. Buish, N. Jess, M. Martinati, and P. L. Lakatos, J. Crohns Colitis, 7(4), 322 – 337 (2013).
Yu. V. Balbaitis, V. E. Kushnits, A. I. Korsunovskii, et al., Nonspecific Ulcerative Colitis [in Russian], Zdorov’ya, Kiev (1986).
V. Yu. Golofeevskii and A. M. Pershko, Diagnosis and Treatment of Nonspecific Ulcerative Colitis in Military Physician Practice [in Russian], (1999).
A. S. Loginov, Intestinal Diseases: Handbook for Physicians [in Russian], (2000).
Encyclopedia of Medicines. Russian Drug Registry (RDR) [in Russian], 12th Ed., RLS-2005 LLC, Moscow (2004).
N. V. Derkach, Anti-inflammatory Activity of Aqueous Extract of Aspen Roots [in Ukrainian], Author’s Abstract of a Candidate Dissertation in Biological Sciences (2006).
A. N. Belovol, et al., Ukrainian Medicines [in Russian], MOH Ukraine, Nats. Farm. Univ., V. P. Chernii and I. A. Zupanets (eds.), Izd. NFU: Zolotye Stranitsy, Kharkov (2005), 512 pp.
Yu. I. Oshchepkova, O. N. Veshkurova, E. A. Rogozhin, et al., Bioorg. Khim., 3, 344 – 349 (2009).
European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes (1986); http: //www.lawmix.ru/abro.php?id=11036.
O. V. Stefanov, Preclinical Drug Trials: Methodical Recommendations [in Ukrainian], (2001).
Yu. I. Oshchepkova, I. I. Tukfatullina, P. G. Merzlyak, et al., Uzb. Biol. Zh., 2, 7 – 11 (2009).
Yu. I. Oshchepkova, S. Son’kina, B. A. Salakhutdinov, et al., Khim. Prir. Soedin., No. 4, 505 – 507 (2010).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 7, pp. 25 – 29, July, 2021.
Rights and permissions
About this article
Cite this article
Amanlikova, D.A., Oshchepkova, Y.I. Influence of Biologically Active Peptides on the Course of Experimental Ulcerative Colitis. Pharm Chem J 55, 679–683 (2021). https://doi.org/10.1007/s11094-021-02477-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-021-02477-y