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Antiproliferative Activity of 3-Cyanocoumarins and 2-Aminochromeno[2,3-b ]Pyridine-3-Carbonitriles, Derivatives of 2-Amino-4H-Chromene-3-Carbonitrile

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Pharmaceutical Chemistry Journal Aims and scope

The antiproliferative activity of the previously synthesized 2-amino-4H-chromene-3-carbonitrile derivatives 4,7-disubstituted 3-cyanocoumarins and 2-aminochromeno[2,3-b]pyridine-3-carbonitriles was studied on 59 cell lines isolated from lung, colon, brain, ovary, kidney, prostate, and breast tumors and leukemia and human melanoma. The reference drugs were dacarbazine, hydroxycarbamide, and cisplatin. It was found that the activity of the test substances was directly related to the nature of the 4- and 7-substituents. 4-Aryl-2-oxo-2H-benzo [h]chromene-3-carbonitriles showed the most pronounced activity and could be of interest as parent substances for potential anticancer drugs.

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Acknowledgments

The work was performed in the framework of a State Task for the Ministry of Education and Science of Russia, Project No. 0849-2020-0003.

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Authors and Affiliations

  1. I. N. Ulyanov Chuvash State University, 15 Moskovskii Prosp, Cheboksary, 428015, Russia

    I. N. Bardasov, A. Yu. Alekseeva, O. V. Ershov & M. A. Mar’yasov

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  1. I. N. Bardasov
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  2. A. Yu. Alekseeva
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  3. O. V. Ershov
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  4. M. A. Mar’yasov
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Correspondence to I. N. Bardasov.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 7, pp. 14 – 17, July, 2021.

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Bardasov, I.N., Alekseeva, A.Y., Ershov, O.V. et al. Antiproliferative Activity of 3-Cyanocoumarins and 2-Aminochromeno[2,3-b ]Pyridine-3-Carbonitriles, Derivatives of 2-Amino-4H-Chromene-3-Carbonitrile. Pharm Chem J 55, 644–647 (2021). https://doi.org/10.1007/s11094-021-02473-2

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  • DOI: https://doi.org/10.1007/s11094-021-02473-2

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