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Identification and Quantitative Determination of Inner-Coordination-Sphere Water in Insoluble Cu2+ and Pb2+ Pectinates

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Pharmaceutical Chemistry Journal Aims and scope

Thermal analysis (DTA, DTGA, and TGA) of insoluble metal pectinates (MPs) of Cu2+ (CuP) and Pb2+ (PbP) showed the presence of high-temperature components (150 – 165 and 150 – 160°C, respectively). Potentiometric alkalimetric titration of CuP and PbP revealed equivalence points at pH 4.87 and 4.95, respectively, that were uncharacteristic of the reagents (9.14 for pectin, 6.42 for Cu acetate, and 7.84 for Pb acetate) and were indicative of the acidic properties of the MPs. The presence of the high-temperature components (>150°C) in the MPs and their ability to manifest acidic properties (pH ~ 5) upon reaction with base were indicative of the presence of inner-coordination-sphere water in the MPs. The simplest formulas of the MPs were expressed as [CuL2(H2O)2] and [PbL(H2O)4] considering the loss of this water and the known ratio of metal cations and pectin monomers (L).

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References

  1. State Drug Registry [in Russian], Moscow (2020); https: //grls.rosminzdrav.ru.

  2. M. D. Mashkovskii, Drugs [in Russian], 16th Ed., Revised and Supplemented, Novaya Volna, Moscow (2019), pp. 374 – 375, 412 – 413.

  3. N. Sh. Kaisheva and A. Sh, Kaishev, Pharmacological Bases for Using Pectins and Alginates [in Russian], RIA-KMV, Pyatigorsk (2016), pp. 16 – 21, 72 – 80, 150 – 152.

  4. N. Sh. Kaisheva, A. Sh. Kaishev, and V. A. Karpenko, in: Collection of Scientific Works “Development, Research, and Monitoring of New Pharmaceutical Products” [in Russian], Izhevsk (2016), pp. 156 – 160.

  5. Yu. Yu. Lur’e, Handbook of Analytical Chemistry: Handbook Edition [in Russian], 6th Ed., Revised and Supplemented, Khimiya, Moscow (2013), pp. 328 – 329.

    Google Scholar 

  6. R. M. C. Dawson, D. C. Elliott, et al. (eds.), Data for Biochemical Research, 3rd Ed., Clarendon Press, Oxford (1986) [Russian translation, Mir, Moscow (1991), pp. 345 – 348].

  7. United States Pharmacopoeia, USP29-NF24, Pectin [9000-69-5], New York, 1647 pp.; https: // www.pharmacopeia.cn; [http: // pharmacopeia.cn / v29240 / usp29nf24s0_m61250.html].

  8. N. Sh. Kaisheva and A. Sh. Kaishev, RU Pat. 2,555,360, Jul. 10, 2015; Byull. Izobret., No. 19 (2015).

  9. N. N. Zheligovskaya and I. I. Chernyaev, Chemistry of Pectinic Compounds [in Russian], Vysshaya Shkola, Moscow (1966), pp. 291 – 298.

    Google Scholar 

  10. M. P. Filippov, Izv. Akad. Nauk MSSR, 4, 80 – 87 (1976).

    Google Scholar 

  11. O. D. Kurilenko, Ya. G. Fabulyak, and V. M. Klimovich, Dopov. Akad. Nauk Ukr. RSR, Ser. B: Geol., Geofiz., Khim. Biol., 4, 332 – 334 (1975).

  12. N. Sh. Kaisheva, RU Pat. 2,206,089, Jun. 10, 2003; Byull. Izobret., No. 16 (2003).

  13. N. Sh. Kaisheva, Author’s Abstract of a Doctoral Dissertation, Pyatigorsk (2004); pp. 15 – 17, 28 – 29.

  14. V. I. Spitsyna and L. I. Martynenko, Coordination Chemistry of Rare-Earth Elements [in Russian], MGU, Moscow (1979), pp. 135 – 136.

    Google Scholar 

  15. E. A. Aleksandrova and N. G. Gaidukova, Analytical Chemistry [in Russian], in 2 books, Book 1. Chemical Methods of Analysis, 3rd Ed., Revised and Supplemented, Yurait, Moscow (2019), pp. 402 – 406.

  16. State Pharmacopoeia of the Russian Federation, 14th Ed., General Pharmacopoeial Monograph GPM. 1.1.0013.15 Statistical processing of results of chemical experiments, MH RF, Moscow (2015).

  17. N. Sh. Kaisheva, Khim.-farm. Zh., 46(8), 51 – 53 (2012).

    Google Scholar 

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Authors and Affiliations

  1. Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University, Ministry of Health of Russia, 11 Kalinina Prosp, Pyatigorsk, 357532, Russia

    N. Sh. Kaisheva & A. Sh. Kaishev

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  1. N. Sh. Kaisheva
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  2. A. Sh. Kaishev
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Correspondence to N. Sh. Kaisheva.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 6, pp. 59 – 64, June, 2021.

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Kaisheva, N.S., Kaishev, A.S. Identification and Quantitative Determination of Inner-Coordination-Sphere Water in Insoluble Cu2+ and Pb2+ Pectinates. Pharm Chem J 55, 627–632 (2021). https://doi.org/10.1007/s11094-021-02468-z

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  • DOI: https://doi.org/10.1007/s11094-021-02468-z

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