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Liquid Crystals: Characteristics, Types of Phases and Applications in Drug Delivery

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Pharmaceutical Chemistry Journal Aims and scope

The present review article relates to some theoretical aspects of liquid crystals, particularly types and phases of liquid crystals. In recent years mesophase has gained a great deal of attention and is yet another exciting lipid-based system for drugs, Proteins, and vaccine delivery. On the whole, the existing research advancement of different phases of liquid crystals as a drug delivery system has been discussed and explored in detail. It is concluded that different phases of liquid crystals are promising to sustain the drug release from the internal nanostructure. Peptide-based therapeutics and enzymes can also be delivered through liquid crystals. Liquid crystals may be the drug carriers of choice soon.

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References

  1. I. Tadwee, S. Shahi, V. Ramteke, et al., Int. J. Pharm. Res. Sci., 1, 6 – 11 (2012).

    CAS  Google Scholar 

  2. Z. Qiang, A. R. Oganov, and Z. Xiang-Feng, Top Curr. Chem., 2014, 345 (2014).

    Google Scholar 

  3. C. C. Mueller-Goymann, Liquid crystals in drug delivery. in: J. Swarbrick, J. C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology, Marcel Dekker, New York – Basel (2002), pp. 834 – 853.

  4. L. K. Omray, Curr. Trends Technol. Sci., 2, 347 – 351, (2013).

    Google Scholar 

  5. C. L. Stevenson, D. B. Bennett, and D. Lechuga-Ballesteros, J. Pharm. Sci., 94, 1861 – 1880 (2005).

    CAS  Google Scholar 

  6. R. Muzzalupo, L. Tavano, S. Nicoletta, and S. Trombina, J. Drug Target., 18, 404 – 411 (2010).

    CAS  PubMed  Google Scholar 

  7. G. V. Rama Rao, M. Triveni, and N. Srinivas Rao, Int. J. Eng. Res., 3, 160 – 165 (2015).

    Google Scholar 

  8. M. R. Fisch, S. Kumar, Introduction to liquid crystals, in: S. Kumar (Ed.), Liquid Crystals: Experimental Study of Physical Properties and Phase Transitions, Cambridge University Press, Cambridge, UK (2001) pp. 1 – 28.

    Google Scholar 

  9. B. Sivaranjini, R. Mangaiyarkarasi, V. Ganesh, et al., Sci. Rep., 8, 8891 (2018). https://doi.org/10.1038/s41598-018-27039-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. D. Andrienko. J. Mol. Liq., 267, 520 – 541 (2018).

    CAS  Google Scholar 

  11. G. S. Ginsburg, D. Atkinson, and D. M. Small, Prog. Lipid Res., 23, 135 – 167 (1984).

    CAS  PubMed  Google Scholar 

  12. K. B. Dada and E. Momoniat, Int. J. Numer. Methods Heat Fluid Flow, 20, 429 – 444 (2010).

  13. G. Rai, D. Jain, Liq. Cryst., 4, 129 – 134 (2010).

    CAS  Google Scholar 

  14. P. P. Gaikwad and M. T. Desai, Int. J Pharm. Res. Rev., 2, 40 – 52 (2013).

    Google Scholar 

  15. P. J. Sinko (Ed.), Martin's Physical Pharmacy and Pharmaceutical Sciences, 5th edition, LippincottWilliams &Wilkins, Philadelphia (2006), pp. 41, 42.

  16. S. T. Hyde, Identification of lyotropic liquid crystalline mesophases. in: K. Holmberg (Ed.), Handbook of Applied Surface and Colloid Chemistry, John Wiley & Sons, Chichester (2001) pp. 201 – 215.

    Google Scholar 

  17. S. K. Owusu-Ware, B. Z. Chowdhry, S. A. Leharne, et al., J. Therm. Anal. Calorim., 127, 415 – 421 (2017).

    CAS  Google Scholar 

  18. K. V. Axenov and S. Laschat, Materials (Basel), 4, 206 – 259 (2011).

    CAS  Google Scholar 

  19. Y. Tyagi, Pharm. Innov. J., 7, 540 – 545 (2018).

    Google Scholar 

  20. M. Kýlýc and Z. Cýnar, J. Mol. Struct. THEOCHEM, 808, 53 – 61 (2007).

    Google Scholar 

  21. J. W. Good, Handbook of Visual Display Technology, pp. 1243 – 1287.

  22. J. A. Rego, J. A. A. Harvey, A. L. MacKinnon, et al., Liq. Cryst., 37, 37 – 43 (2010).

    CAS  Google Scholar 

  23. A. Avazpour and S. M. Hekmatzadeh, Iranian J. Phys. Res., 14, 27 – 65 (2014).

    Google Scholar 

  24. L. A. Madsen, T. J. Dingemans, M. Nakata, et al., Phys. Rev. Lett., 92, 145 – 505 (2004).

    Google Scholar 

  25. I. Dierking. Symmetry, 6, 444 – 472 (2014).

    Google Scholar 

  26. J. A. Castellano, in: Liquid Gold: The Story of Liquid Crystal Displays and the Creation of an Industry,World Scientific Publishing (2005), ISBN 978-981-238-956-5.

  27. A. R. E. Bras, T. Casimiro, J. Caldeira, et al., J. Chem. Eng. Data, 50, 1857 – 1860 (2005).

    CAS  Google Scholar 

  28. S. Kubo, Z. Z. Gu, K. Takahashi, et al., J. Am. Chem. Soc., 124, 10950 – 10951 (2002).

    CAS  PubMed  Google Scholar 

  29. P. Kirsch, M. Bremer, F. Huber, et al., J. Am. Chem. Soc., 123, 5414 – 5417 (2001).

    CAS  PubMed  Google Scholar 

  30. I. Chashechnikova, L. Dolgov, T. Gavrilko, et al., J. Mol. Struct., 744 – 747, 563 – 571 (2005).

  31. I. Dierking, Textures of Liquid Crystals, Wiley-VCH Verlag, Weinheim (2003), ISBN 3-527-30725-7.

    Google Scholar 

  32. A. Yu. Bobrovsky, N. I. Boiko, V. P. Shibaev, Liq. Cryst., 27, 219 – 223 (2000).

    CAS  Google Scholar 

  33. N. Amaoki, Adv. Mater., 13, 1135 – 1147 (2001).

    Google Scholar 

  34. A. Ryabchun and A. Bobrovsky, Adv. Opt. Mater., 6, 1800335 (2018). https://doi.org/10.1002/adom.201800335.

    Article  CAS  Google Scholar 

  35. H. Kleinert and K. Maki, Fortsch. Phys., 29, 219 – 259 (1981).

    CAS  Google Scholar 

  36. I. Dierking. Symmetry, 6, 444 – 472, (2014). doi:https://doi.org/10.3390/sym6020444

    Article  CAS  Google Scholar 

  37. R. Berardi, S. Orlandi, D. J. Photinos, et al., Phys. Chem. Chem. Phys., 4, 770 – 777 (2002).

    CAS  Google Scholar 

  38. G. Singh, S. Kumar, and S.-W. Kang, Ref. Module Mater. Sci. Mater. Eng. (2016). https://doi.org/10.1016/B978-0-12-803581-8.01257-1.

  39. K. Binnemans, Chem. Rev., 105, 4148 – 4204 (2005).

    CAS  PubMed  Google Scholar 

  40. P. J. Repasky, D. M. Agra-Kooijman, S. Kumar, et al., J. Phys. Chem. B, 120, 2829 – 2837 (2016).

    CAS  PubMed  Google Scholar 

  41. A. Gowda and S. Kumar, Materials (Basel), 11, 382, (2018). doi: https://doi.org/10.3390/ma11030382.

    Article  CAS  Google Scholar 

  42. S. Kumar, Chem. Soc. Rev., 35, 83 – 109 (2006).

    CAS  PubMed  Google Scholar 

  43. E. Paineau, M. Krapf, M. Amara, et al., Nat. Commun., 7, 10271 (2016). https://doi.org/10.1038/ncomms10271.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. R. J. Bushby, O. R. Lozman, Curr. Opin. Coloid Interf. Sci., 7, 343 – 354 (2002) DOI: https://doi.org/10.1016/s1359-0294(02)00085-7.

    Article  CAS  Google Scholar 

  45. F. A. Olate, J. A. Ulloa, J. M. Vergara, et al., Liq. Cryst., 43, 811 – 827 (2016).

    CAS  Google Scholar 

  46. D. Andrienko, Introduction to Liquid Crystals, IMPRS School, Bad Marienberg (2006).

    Google Scholar 

  47. M. Gharbia, A. Gharbi, H. T. Nguyen, et al., Curr. Opin. Colloid Interf. Sci. 7, 312 – 325 (2002).

    CAS  Google Scholar 

  48. J. M. Elliott, J. R. Chipperfield, S. Clark, and E. Sinn, Inorg. Chem., 40, 6390 – 6396 (2001).

    CAS  PubMed  Google Scholar 

  49. D. M. Huck, H. L. Nguyen, P. N. Horton, et al., Polyhedron, 25 (2), 307 – 324 (2006).

    CAS  Google Scholar 

  50. R. L. Coelho, E. Westphal, D. Z. Mezalira, and H. Gallardo, Liq. Cryst., 44, 405 – 416 (2017).

    CAS  Google Scholar 

  51. T. Yasuda, H. Ooi, J. Morita, et al., Adv. Funct. Mater., 19, 411 – 419 (2009).

    CAS  Google Scholar 

  52. S. O. Kim, C. M. Koo, I. J. Chung, et al., Macromolecules, 34, 8961 – 8967 (2001).

    CAS  Google Scholar 

  53. F. Ammar-Khodja, S. Guermouche, M. H. Guermouche, et al., Chroma, 70, 497 – 502 (2009).

    CAS  Google Scholar 

  54. G. W. Gray and P. A. Winsor (Eds.), Liquid Crystals and Plastic Crystals, Ellis Horwood, Chichester (1974), Vol. 1, p. 19.

  55. C. Guo, J. Wang, F. Cao, et al., Drug Discov. Today, 15, 1032 – 1040 (2010).

    CAS  PubMed  Google Scholar 

  56. D. H. Kim, A. Jahn, S. J. Cho, et al., J. Pharm. Invest., 45, 1 – 11 (2015).

    CAS  Google Scholar 

  57. Q. Liang, P. Liu, C. Liu, et al., Polymer. 46, 6258 – 6265 (2005).

    CAS  Google Scholar 

  58. G. Ungar and X. Zeng, Soft Matter, 1, 95 – 106 (2005).

    CAS  PubMed  Google Scholar 

  59. W. Sun, J. J. Vallooran, and R. Mezzenga, Langmuir, 31, 4558 – 4565 (2015). doi: 10.1021 / acs.langmuir.5b00579.

  60. W. Sun, J. J. Vallooran, and R. Mezzenga, Langmuir, 31, 4558 – 4565 (2015).

    CAS  PubMed  Google Scholar 

  61. W. Sun, J. J. Vallooran, R. Mezzenga, et al., J. Phys. Chem. Lett., 7, 1507 – 1512 (2016).

    CAS  PubMed  Google Scholar 

  62. N. Tran, A. M. Hawley, J. Zhai, et al., Langmuir, 32, 4509 – 4520 (2016).

    CAS  PubMed  Google Scholar 

  63. D. Wang, Y. Cao, M. Cao, et al., Chem. Phys. Chem., 7, 2079 – 2087 (2016).

    Google Scholar 

  64. E. Nazaruk, P. Miszta, S. Filipek, et al., Langmuir, 31, 12753 – 12761 (2015).

    CAS  PubMed  Google Scholar 

  65. Q. Liu, Y. Dong, B. J. Boyd, Langmuir, 32, 5155 – 5161 (2016).

    CAS  PubMed  Google Scholar 

  66. B. Roy, S. Satpathi, P. Hazra, Langmuir, 32, 3057 – 3065 (2016).

    CAS  PubMed  Google Scholar 

  67. C. J. Drummond and C. Fong, Curr. Opin. Colloid Interf. Sci., 4, 449 – 456 (1999).

    CAS  Google Scholar 

  68. A. Gezae Daful, V. A. Baulin, J. B. Avalos, et al., J. Phys. Chem. B, 115, 3434 – 3443 (2011).

    PubMed  Google Scholar 

  69. D. Lombardo, M. A. Kiselev, S. Magazù, et al., Adv. Condens. Matter Phys., 2015, Article ID 151683 (2015). 10.1155/2015/151683.

  70. J. Zhao, Z. N. Wang, X. L. Wei, et al., Indian J. Chem., 50, 641 – 649 (2011).

    Google Scholar 

  71. A. Yaghmur and O. Glatter, Adv. Colloid Interf. Sci. 147 – 148, 333 – 342 (2009).

  72. P. T. Spicer, Curr. Opin. Colloid Interf. Sci. 10, 274 – 279 (2005).

    CAS  Google Scholar 

  73. L. Sagalowicz, M. E. Leser, H. J. Watzke, et al., Trends Food Sci. Technol., 17, 204 – 214 (2006).

    CAS  Google Scholar 

  74. K. Larsson, Curr. Opin. Colloid Interf. Sci., 5, 64 – 69 (2000).

    CAS  Google Scholar 

  75. J. Y. T. Chong, X. Mulet, L. J. Waddington, et al., Soft Matter, 7, 4768 – 4777 (2011).

    CAS  Google Scholar 

  76. J. Y. T. Chong, X. Mulet, L. J. Waddington, et al., Langmuir, 28, 9223 – 9232 (2012).

    CAS  PubMed  Google Scholar 

  77. Y. Chen, P. Ma, S. Gui, BioMed Res. Int., 2014, Article ID 815981 (2014). https://doi.org/10.1155/2014/815981.

    Article  PubMed  PubMed Central  Google Scholar 

  78. M. Gontsarik, M. T. Buhmann, A. Yaghmur, et al., J. Phys. Chem. Lett., 7, 3482 – 3486 (2016).

    CAS  PubMed  Google Scholar 

  79. T. E. Hartnett, K. Ladewig, A. J. O'Connor, et al., J. Phys. Chem. B, 118, 7430 – 7439 (2014).

    CAS  PubMed  Google Scholar 

  80. T. Kaasgaard and C. J. Drummond, Phys. Chem. Chem. Phys., 8, 4957 – 4975 (2006).

    CAS  PubMed  Google Scholar 

  81. L. Bitan-Cherbakovsky, D. Libster, D. Appelhans, et al., J. Phys. Chem. B, 118, 4016 – 4024 (2014).

    CAS  PubMed  Google Scholar 

  82. S. E. Friberg, C. S. Wohn, and F. E. Lockwood. J. Pharm. Anal., 74, 771 – 773 (1985).

    CAS  Google Scholar 

  83. M. K. Nemanic and P. M. Elias, J. Histochem. Cytochem., 28, 573 – 578 (1980).

    CAS  Google Scholar 

  84. Y. D. Dong, I. Larson, T. Hanley, et al., Langmuir, 22, 9512 – 9518 (2006).

    CAS  PubMed  Google Scholar 

  85. J. Bender, M. B. Ericson, N. Merclin, et al., J. Control. Release, 106, 350 – 360 (2005).

    CAS  PubMed  Google Scholar 

  86. L. B. Lopes, J. L. Lopes, D. C. Oliveira, et al., Eur. J. Pharm. Biopharm., 63, 146 – 155 (2006).

    CAS  PubMed  Google Scholar 

  87. L. B. Lopes, J. H. Collett, and M. V. Bentley, Eur. J. Pharm. Biopharm., 60, 25 – 30 (2005).

    CAS  PubMed  Google Scholar 

  88. L. B. Lopes, D. A. Ferreira, and D. Paula, Pharm. Res., 23, 1332 – 1342 (2006).

    CAS  PubMed  Google Scholar 

  89. L. B. Lopes, F. F. Speretta, and M. V. Bentley, Eur. J. Pharm. Sci., 32, 209 – 215 (2007).

    CAS  PubMed  Google Scholar 

  90. E. Esposito, R. Cortesi, M. Drechsler, et al., Pharm. Res., 22, 2163 – 2173 (2005).

    CAS  PubMed  Google Scholar 

  91. M. Cohen-Avrahami, A. Aserin, N. Garti, Colloid Surf. B, 77, 131 – 138 (2010).

    CAS  Google Scholar 

  92. D. Yariv, R. Efrat, D. Libster, et al., Colloid Surf. B, 78, 185 – 192 (2010)

    CAS  Google Scholar 

  93. L. S. Helledi, and L. Schubert, Drug Dev. Ind. Pharm., 27, 1073 – 1081 (2001).

    CAS  PubMed  Google Scholar 

  94. M. Aytekin, R. N. Gursoy, S. Ide, et al., Drug Dev Ind Pharm., 39, 228 – 239 (2013).

    CAS  PubMed  Google Scholar 

  95. A. Namdeo, N. K. Jain, J. Control. Release, 82, 223 – 236 (2002).

    CAS  Google Scholar 

  96. L. Brinon, S. Geiger, V. Alard, et al., J. Control. Release, 60, 67 – 76 (1999).

    CAS  PubMed  Google Scholar 

  97. D. Libster, A. Aserin, E. Wachtel, et al., J. Colloid Interf. Sci., 308, 514 – 524 (2007).

    CAS  Google Scholar 

  98. W. Schuetze, C. C. Muiier-Goymann, Colloid. Polym. Sci., 269, 85 – 90 (1992).

    Google Scholar 

  99. K. Yamada, J. Yamashita, H. Todo, et al., J. Oleo Sci., 60, 31 – 40 (2011).

    CAS  PubMed  Google Scholar 

  100. A. Tambade, N. H. Aloorkar, N. S. Dabane, et al., Am. J. Adv. Drug Deliv., 2, 364 – 386 (2014).

    Google Scholar 

  101. P. Hiwale, S. Lampis, S. Murgia, et al., J. Dispesr. Sci. Technol., 5, 1286 – 1293 (2017).

    Google Scholar 

  102. D. I. Nesseem, J. Pharm. Biomed. Anal., 26, 387 – 399 (2001).

    CAS  Google Scholar 

  103. J. M. Hosmer, A. A. Steiner, and L. B. Lopes, Pharm. Res., 30, 694 – 706 (2013).

    CAS  PubMed  Google Scholar 

  104. I. Martiel, N. Baumann, J. J. Vallooran, et al., J. Control. Release, 204, 78 – 84 (2015).

    CAS  PubMed  Google Scholar 

  105. Y. Li, C. Dong, D. Cun, et al., AAPS PharmSciTech, 17, 767 – 777 (2016).

    CAS  PubMed  Google Scholar 

  106. M. H. Oyafuso, F. C. Carvalho, L. A. Chiavacci, et al., J. Nanosci. Nanotechnol., 15, 817 – 826 (2015).

    CAS  PubMed  Google Scholar 

  107. P. A. Rocha-Filho, M. Maruno, M. Ferrari, et al., Molecules, 21, 680 (2016).

    PubMed Central  Google Scholar 

  108. A. L. Carvalho, J. A. Silva, A. A. Lira, et al., J. Pharm. Sci., 105, 2188 – 2193 (2016)

    CAS  PubMed  Google Scholar 

  109. Y. Xu, M. Laupheimer, N. Preisig, et al., Langmuir, 31, 8589 – 8598 (2015).

    CAS  PubMed  Google Scholar 

  110. L. N. Borgheti-Cardoso, L. V. Depieri, H. Diniz, et al., Eur. J. Pharm. Sci., 58, 72 – 82 (2014).

    CAS  PubMed  Google Scholar 

  111. L. N. Borgheti-Cardoso, L. V. Depieri, S. A. A. Kooijmans, et al., Eur. J. Pharm. Sci., 74, 103 – 117 (2015).

    CAS  PubMed  Google Scholar 

  112. R. Petrilli, J. O. Eloy, F. S. G. Praça, et al., J. Biomed. Nanotechnol., 12, 1063 – 1075 (2016).

    CAS  PubMed  Google Scholar 

  113. N. Naga, A. Okada, Y. Satoh, et al., Liq. Cryst., 43, 1616 – 1625 (2016).

    CAS  Google Scholar 

  114. B. Fonseca-Santos, A. M. Santos, C. F. Rodero, et al., Int. J. Nanomed., 11, 4553 – 4562. (2016).

  115. B. J. Boyd, D. V. Whittaker, S. Khoob, et al., Int. J. Pharm., 309, 218 – 226 (2006).

    CAS  PubMed  Google Scholar 

  116. X. Ren, D. Svirskis, R. G. Alany, et al., Int. J Pharm., 431, 130 – 137 (2012).

    CAS  PubMed  Google Scholar 

  117. Z. Ali, P. K. Sharma, M. H. Warsi. J. App. Pharm. Sci., 6, 204 – 208 (2016).

    CAS  Google Scholar 

  118. S. Mackeben, M. Muller, C. C. Muller-Goymann, Colloids Surf. A: Physicochem. Eng. Aspects, 183 – 185, 699 – 713 (2001).

  119. R. Liu, S. Wang, S. Fang, et al., Nanoscale Res. Lett., 11, 254 (2016)

    PubMed  PubMed Central  Google Scholar 

  120. W. J. Wu, J. Li, L. Wu, et al., AAPS PharmSciTech, 14, 1063 – 1071 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

  121. D. Achouri, M. Sergent, A. Tonetto, et al., Drug Dev. Ind. Pharm., 41, 493 – 501 (2015).

    CAS  PubMed  Google Scholar 

  122. P. Verma and M. Ahuja, Drug Deliv., 23, 3043 – 3054 (2016).

    CAS  PubMed  Google Scholar 

  123. M. H. Shah and A. Paradkar, Int. J. Pharm., 294, 161 – 171 (2005).

    CAS  PubMed  Google Scholar 

  124. S. Al-Sayed, E. Khalil, H. Ibrahimc, et al., Eur. J. Pharm. Biopharm., 53, 343 – 352 (2002).

    Google Scholar 

  125. B. J. Boyd, S. M. Khoo, D. V. Whittaker, et al., Int. J. Pharm., 340, 52 – 60 (2007).

    CAS  PubMed  Google Scholar 

  126. R. Negrini and R. Mezzenga, Langmuir, 27, 5296 – 5303 (2011).

    CAS  PubMed  Google Scholar 

  127. A. C. Pham, L. Hong, O. Montagnat, et al., Mol. Pharm., 13, 280 – 286 (2016).

    CAS  PubMed  Google Scholar 

  128. H. Chung, J. Kim, J. Y. Um, et al., Diabetologia, 45, 448 – 451 (2002).

    CAS  PubMed  Google Scholar 

  129. W. R. Kadhum, T. Oshizaka, H. Ichiro, et al., Eur. J. Pharm. Sci., 88, 282 – 290 (2016).

    CAS  PubMed  Google Scholar 

  130. J. Lai, J Chen, Y. Lu, et al., AAPS PharmSciTech, 10, 960 – 966 (2009).

    CAS  PubMed  PubMed Central  Google Scholar 

  131. N. Zeng, X. Gao, Q. Hu, et al., Int. J. Nanomed., 7, 3703 – 3718 (2012).

    CAS  Google Scholar 

  132. Q. Luo, T. Y. Lin, C. Y. Zhang, et al., Int. J. Pharm., 493, 30 – 39 (2015).

    CAS  PubMed  Google Scholar 

  133. C. M. Spillmann, J. Naciri, W. R. Algar, et al., ACS Nano, 8, 6986 – 6997 (2014).

    CAS  PubMed  Google Scholar 

  134. C. Souza, E. Watanabe, L. Neves, et al., J. Pharm Sci., 103, 3914 – 3923 (2014).

    CAS  PubMed  Google Scholar 

  135. Z. Yang, M. Chen, M. Yang, et al., Int. Nanomed., 9, 327 – 336 (2014).

    Google Scholar 

  136. A. B. Bhatt, T. J. Barnes, C. A. Prestidge. Curr. Drug Deliv., 12, 47 – 55 (2015).

    CAS  PubMed  Google Scholar 

  137. J. Bernegossi, G. Maria, F. Calixto, et al., Molecules, 21, 37 (2016).

    Google Scholar 

  138. D. R. Lee, J. S. Park, I. H. Bae, et al., Int. Nanomed., 11, 853 – 871 (2016).

    CAS  Google Scholar 

  139. C. C. Muller-Goymann, Eur. J. Pharma. Biopharm., 58, 343 – 356 (2004).

    CAS  Google Scholar 

  140. E. Mathiowitz, J. Jacob, D. Chickering, Y. Jong, and E. Edwards, Liquid Crystalline Polymers, US20020155146A1.

  141. Jin Young Ko, Ji Yeon Kim, So Hyun Park, SungWon An, and Min Hyo Ki, Sustained-Release Lipid Pre-Concentrate of Pharmacologically Active Substance and Pharmaceutical Composition Comprising the Same, WO2013032207A1.

  142. W. Schuberth and J. F. Hanny. Cholesteric Compositions, US4301023A

  143. G. Cioca, J. A. Hayward, M. L. Tan, M. Herstein, W. P. Smith, Liquid Crystal Containing Cosmetic and Pharmaceutical Compositions and Methods for Utilizing Such Compositions, US4999348A.

  144. R. Akamatsu, M. Fujii, T. Sakaguchi, and E. Horisawa, Liquid Crystals Emulsion Type Pharmaceutical Composition Containing Cyclosporine and Therapeutic Method of Treating Cutaneous Disease Therewith. CA2697756A1.

  145. M. S. Ferritto, Z. Lin, and W. J. Schulz, Jr., Silicone Liquid Crystals, Vesicles, and Gels, US 6608126.

  146. K. R. Thorat, and R. B. Laware, J. Drug Deliv. Therap., 9, 116 – 125 (2019).

    CAS  Google Scholar 

  147. H. A. Abo El-Enin, J. Pharm. Innov., 15, 80 – 93 (2020). 10.1007 / s12247-019-09371-x

  148. M. Kazemi, J. Varshosaz, M. Tabbakhian, Adv. Biomed. Res., 7, 126, (2018).

    PubMed  PubMed Central  Google Scholar 

  149. D. Nagaraju, K. Y. Shravan, S. Pavani, et al., Glob. J. Pharm.. Sci., 7, 5, 555721 (2019). DOI: 10.19080/GJPPS. 2019.07.555721.

  150. Z. Yang, X. Liang, X. Jiang, et al., Molecules, 23, 9, pii: E2275. (2018). doi: https://doi.org/10.3390/molecules23092275.

  151. A. Yaghmur, B. V. Tran, S. M. Moghimi, Molecules, 16, (2020). 25doi:10.3390/molecules25010016.

  152. M. Mierzwa, A. Cytryniak, P. Krysinski, et al., Nanomaterials, 9, 636, (2019). doi: https://doi.org/10.3390/nano9040636

    Article  CAS  PubMed Central  Google Scholar 

  153. L. Zhang, J. Li, and D. Tian, Cell Death Disease, 11, (2020). 10.1038/s41419-019-2182-0

  154. L. Boge, K. Hallstensson, L. Ringstad, et al., Eur. J. Pharm. Biopharm., 134, 60 – 67, (2019). doi: https://doi.org/10.1016/j.ejpb.2018.11.009.

    Article  CAS  PubMed  Google Scholar 

  155. H. A. l-Enin, and A. H. Al-Shanbari, Saudi Pharm. J., 26, 790 – 800, (2018). 10.1016/j.jsps.2018.04.004

  156. P. Astolfi, E. Giorgini, V. Gambini, et al., Langmuir, 33, 12369 – 12378 (2017).

    CAS  PubMed  Google Scholar 

  157. H. Wang, P. B. Zetterlund, C. Boyer., et al., J. Colloid Interf. Sci., 546, 240 – 250 (2019)

    CAS  Google Scholar 

  158. Q. Q. Shan, X. J. Jiang, F. Y. Wang, et al., Drug Deliv., 26, 490 – 498 (2019). https://doi.org/10.1080/10717544.2019.1602796

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  159. S. Pisano, M. Giustiniani, L. Francis, et al., Biomed. Microdevices, 21, (2019). https://doi.org/10.1007/s10544-019-0385-x

  160. J. Mahajan, N. Gujarathi, A. Jadhav, et al., Asian J. Pharma. Res. Dev., 6, 75 – 80 (2018). 10.22270/ajprd.v6i3.349

  161. M. Ola, R. Bhaskar, and G. Patil, J. Drug Deliv. Therap., 8, 4, 93 – 101, (2018).

  162. H. Zhang and Z.Wang, Int. J. Pharm., 565, 283 – 293, (2019). doi:https://doi.org/10.1016/j.ijpharm.2019.05.021

    Article  CAS  PubMed  Google Scholar 

  163. M. Chountoulesi, N. Pippa, S. Pispas, et al., Int. J. Pharm, 550, 57 – 70, (2018). doi:https://doi.org/10.1016/j.ijpharm.2018.08.003

    Article  CAS  PubMed  Google Scholar 

  164. J. Wan, S. Wang, Z. Gui, et al., Eur. J. Pharma. Sci., 125, 93 – 101, (2018). doi:https://doi.org/10.1016/j.ejps.2018.09.018

    Article  CAS  Google Scholar 

  165. J. Fan, F. Liu, and Z. Wang, Int. J. Pharm., 497, 248 – 254, (2016). doi:https://doi.org/10.1016/j.ijpharm.2015.12.008

    Article  CAS  PubMed  Google Scholar 

  166. X. Yu, W. Zhou, H. Wanget al., Drug Deliv., 26, 376 – 383 (2019). DOI: 10.1080/10717544.2019.1587046

  167. X. Zhang, Y. Xiao, Z. Huang, et al., Drug Deliv., 27, 449 – 459 (2020). DOI: https://doi.org/10.1080/10717544.2020.1736210

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  168. Y. Wei, J. Zhang, Y. Zheng, et al., RSC Adv., 9, 6287 – 6298, (2019).

    CAS  Google Scholar 

  169. M. S. Freag, A. S. Torky, M. M. Nasra, et al., Nanomedicine, 14, 931 – 954 (2019). doi: 10.2217/nnm-2018–0345.

  170. N. A. Elgindy, M. M. Mehanna, S. M. Mohyeldin, Int. J. Pharm., 501, 167 – 179 (2016). doi: https://doi.org/10.1016/j.ijpharm.2016.01.049.

    Article  CAS  PubMed  Google Scholar 

  171. H. Badie, and H. Abbas, Drug Dev. Ind. Pharm., 44, 2013 – 2025 (2018). doi:https://doi.org/10.1080/03639045.2018.1508220

    Article  CAS  PubMed  Google Scholar 

  172. H. M. Abdelaziz, A. O. Elzoghby, M. W. Helm, et al., Int. J. Nanomed., 14, 499 – 517 (2019). doi: https://doi.org/10.2147/IJN.S188335.

    Article  CAS  Google Scholar 

  173. M. S. Freag, Y. S. Elnaggar, D. A. Abdelmonsif, et al., Int. J. Nanomed., 11, 4799 – 4818 (2016).

    CAS  Google Scholar 

  174. M. N. Musa, S. R. David, I. N. Zulkipli, et al., Bio Impacts, 7, 227 – 239 (2017).

    CAS  Google Scholar 

  175. R. Liu, S. Wang, S. Fang, et al., Nanoscale Res. Lett., 11, (2016). https://doi.org/10.1186/s11671-016-1471-0

  176. D. Wang, B. Ma, Z. Wang, et al., Soft Matter, 15, 9011 – 9017 (2019).

    CAS  PubMed  Google Scholar 

  177. C. Gazga-Urioste, E. Rivera-Becerril, G. Pérez-Hernández, et al., Drug Dev. Ind. Pharm., 45, 168 – 176 (2019). DOI: https://doi.org/10.1080/03639045.2018.1526188

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Krishna Institute of Pharmacy, Krishna Institute of Medical Sciences Deemed to Be University, Karad, 415110, India

    Amol Shete & Rajendra Doijad

  2. Sant Gajanan Maharaj College of Pharmacy, Chinchewadi, Mahagoan, MS, 416503, India

    Sameer Nadaf & Suresh Killedar

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  1. Amol Shete
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  2. Sameer Nadaf
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Shete, A., Nadaf, S., Doijad, R. et al. Liquid Crystals: Characteristics, Types of Phases and Applications in Drug Delivery. Pharm Chem J 55, 106–118 (2021). https://doi.org/10.1007/s11094-021-02396-y

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