A new diaminocarbene cis-palladium(II) complex containing a 2-aminobenzoxazole ligand was synthesized by reacting cis-[PdCl2(CNCy)2] and 2-aminobenzoxazole. The structure and composition of the obtained complex were proven by NMR spectroscopy and high-resolution mass spectrometry. The cytotoxicities of the obtained complex and structurally similar palladium(II) complexes containing a 2-aminothiazole ligand were tested against human cancer cells of various histogenesis (MCF-7, HL60, HeLa, DLD1, A431). The activities of several complexes against cancer cells were higher than those of the reference drug cisplatin and the free ligands, i.e., 2-aminooxazole and substituted 2-aminothiazoles.
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References
T. C. Johnstone, K. Suntharalingam, and S. J. Lippard, Chem. Rev., 116, 3436 – 3486 (2016).
F. Huq, J. Q. Yu, and P. Beale, “Studies on new platinum compounds,” in: Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy. Molecular Mechanisms and Clinical Applications, A. Bonetti, R. Leone, F. M. Muggia, and S. B. Howell (eds.), Humana Press, New York (2009), pp. 11 – 17.
E. A. Popova, R. E. Trifonov, and V. A. Ostrovskii, Russ. Chem. Rev., 88(6), 644 – 676 (2019).
E. A. Popova, A. V. Protas, and R. E. Trifonov, Anti-Cancer Agents Med. Chem., 17, 1856 – 1868 (2017).
M. N. Hopkinson, C. Richter, M. Schedler, and F. Glorius, Nature, 510, 485 (2014).
W. Wang, L. Cui, P. Sun, et al., Chem. Rev., 118, 9843 – 9929 (2018).
S. Y. Hussaini, R. A. Haque, and M. R. Razali, J. Organomet. Chem., 882, 96 – 111 (2019).
W. Liu and R. Gust, Coord. Chem. Rev., 329, 191 – 213 (2016).
V. P. Boyarskiy, N. A. Bokach, K. V. Luzyanin, and V. Yu. Kukushkin, Chem. Rev., 115(7), 2698 – 2779 (2015).
A. S. Mikherdov, A. S. Novikov, M. A. Kinzhalov, et al., Inorg. Chem., 57(6), 3420 (2018).
A. S. Mikherdov, A. S. Novikov, M. A. Kinzhalov, et al., Crystals, 8(3), 112 (2018).
A. S. Mikherdov, Yu. A. Orekhova, and V. P. Boyarskii, Zh. Org. Khim., 88(10), 1677 (2018); A. S. Mikherdov, Yu. A. Orekhova, and V. P. Boyarskii, Russ. J. Gen. Chem., 88(10), 2119 (2018).
A. S. Mikherdov, S. V. Baikov, I. K. Proskurina, et al., Zh. Org. Khim., 89(10), 1572 – 1579 (2019); A. S. Mikherdov, S. V. Baikov, I. K. Proskurina, et al., Russ. J. Gen. Chem., 89, 2062 – 2068 (2019).
A. S. Mikherdov, M. A. Kinzhalov, A. S. Novikov, et al., J. Am. Chem. Soc., 138, 14129 – 14137 (2016).
T. V. Serebryanskaya, M. A. Kinzhalov, V. Bakulev, et al., New J. Chem., 44(15), 5762 – 5773 (2020).
T. Mosmann, J. Immunol. Methods, 65(1 – 2), 55 – 63 (1983).
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The work was performed using equipment of resource centers of St. Petersburg State University “Magnetic Resonance Research Methods” and “Analytical Methods for Compounds” with financial support from the RFBR (Project 18-03-00119-a).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 2, pp. 20 – 23, February, 2021.
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Boyarskii, V.P., Mikherdov, A.S., Baikov, S.V. et al. Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents. Pharm Chem J 55, 130–132 (2021). https://doi.org/10.1007/s11094-021-02393-1
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DOI: https://doi.org/10.1007/s11094-021-02393-1