Skip to main content
SpringerLink
Log in

Anti-Inflammatory Activity of Benzyl Glycosides from the Flowers of Lilium Asiatic Hybrids

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Repeated column chromatography of solvent fractions extracted from the flowers of Lilium Asiatic hybrids ensured purification of three benzyl glycosides I – III, which were reliably identified based on the analysis of various spectroscopic data. Compounds I – III (20 μg/mL) reduced nuclear factor-kappa B (NF-kB) (p-p65/p-65) by 9.64 ± 0.66%, 30.98 ± 1.08%, and 54.04 ± 1.12%, respectively. Compounds II and III markedly inhibited the expression of vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor (TNF)-α-stimulated human aortic smooth muscle cells (HASMCs) by 38.68 ± 2.52% and 37.9 ± 2.76%, respectively. Compound III significantly suppressed U937 monocytes attachment to the TNF-α-stimulated HASMCs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. X. X. Hong, J. G. Luo, C. Guo, et al., Carbohydr. Res., 361, 19 – 26 (2012).

    Article  CAS  Google Scholar 

  2. X. T. Liu, Z. Z. Wang, W. Xiao, et al., Phytochemistry, 69(6), 1411 – 1418 (2008).

    Article  CAS  Google Scholar 

  3. X. Wang and G. Q. Wu, J. Chem. Res., 38(10), 577 – 579 (2014).

    Article  CAS  Google Scholar 

  4. H. Xu, B. Zhao, Y.Wang, et al., J. Chem. Res., 39(5), 260 – 262 (2015).

    Article  CAS  Google Scholar 

  5. Y. Matsuo, R. Takaku, and Y. Mimaki, Molecules, 20(9), 16255 – 16265 (2015).

    Article  CAS  Google Scholar 

  6. M. Yamagishi, Sci. Hortic., 163, 27 – 36 (2013).

    Article  CAS  Google Scholar 

  7. R. Nørbæk and T. Kondo, Phytochemistry, 50(7), 1181 – 1184 (1999).

    Article  Google Scholar 

  8. M. Yamagishi, S. Kishimoto, and M. Nakayama, Plant Breeding, 129, 100 – 107 (2010).

    Article  CAS  Google Scholar 

  9. N. N. Thi, H. S. Song, E. J. Oh, et al., Appl. Biol. Chem., 60(5), 527 – 533 (2017).

    Article  CAS  Google Scholar 

  10. S. H. Cho, J. M. Lee, J. P. Rodriguez, et al., Appl. Biol. Chem., 60(2), 109 – 111 (2017).

    Article  CAS  Google Scholar 

  11. Y. G. Lee, S. A. Jang, K. H. Seo, et al., Chem. Biodivers., 15(4), e1800026 (2018).

    Article  Google Scholar 

  12. H. J. Koo, Y. Y. Sung, and H. K. Kim, Mol. Med. Rep., 7(2), 379 – 383 (2013).

    Article  CAS  Google Scholar 

  13. H. J. Koo, E. H. Sohn, S. Pyo, et al., Int. J. Mol. Med., 35(4), 915 – 924 (2015).

    Article  CAS  Google Scholar 

  14. M. J. Shapiro, J. Org. Chem., 42(4), 762 – 763 (1977).

    Article  CAS  Google Scholar 

  15. P. J. Williams, C. R. Strauss, B. Wilson, et al., Phytochem., 22(9), 2039 – 2041 (1983).

    Article  CAS  Google Scholar 

  16. D. Chassagne, J. Crouzet, C. L. Bayonove, et al., Phytochem., 41(6), 1497 – 1500 (1996).

    Article  CAS  Google Scholar 

  17. E. Kawahara, M. Fujii, K. Kato, et al., Chem. Pharm. Bull., 53(8), 1058 – 1061 (2005).

    Article  CAS  Google Scholar 

  18. J. Y. Lee, M. S. Lee, J. W. Choi, et al., Inflammation, 35(5), 1650 – 1658 (2012).

    Article  CAS  Google Scholar 

  19. N. D. Tommasi, L. Rastrelli, J. Cumanda, et al., Phytochemistry, 42(1), 163 – 167 (1996).

    Article  CAS  Google Scholar 

  20. S. Kalaiselvan and M. K. Rasool, J. Immunotoxicol., 13(4), 509 – 525 (2016).

    Article  CAS  Google Scholar 

  21. Y. Ranneh, F. Ali, A. M. Akim, et al., Appl. Biol. Chem., 60(3), 327 – 338 (2017).

    Article  CAS  Google Scholar 

  22. J. Liu, J. Tang, Y. Zuo, et al., Pharmacol. Res., 111, 305 – 315 (2016).

    Google Scholar 

  23. Q. Yu, K. Zeng, X. Ma, et al., Int. Immunopharmacol., 38, 104 – 114 (2016).

    Article  CAS  Google Scholar 

  24. M. S. Kim and J. Y. Kim, Appl. Biol. Chem., 60(5), 553 – 561 (2017).

    Article  CAS  Google Scholar 

  25. S. Y. Lee, K. H. Kim, I. K. Lee, et al., Arch. Pharm. Res., 35(3), 415 – 421 (2012).

    Article  CAS  Google Scholar 

  26. C. Alexander and E. T. Rietschel, J. Endotoxin. Res., 7(3), 167 – 202 (2001).

    CAS  PubMed  Google Scholar 

  27. H. J. Gu, I. B. Song, H. J. Han, et al., Appl. Biol. Chem., 61(2), 227 – 233 (2018).

    Article  CAS  Google Scholar 

  28. E. H. Lee, J. H. Cho, D. H. Kim, et al., Appl. Biol. Chem., 60(1), 63 – 71 (2017).

    Article  CAS  Google Scholar 

  29. M. Guha and N. Mackman, Cell. Signal., 13(2), 85 – 94 (2001).

    Article  CAS  Google Scholar 

  30. X. Li, J. Shen, Y. Jiang, et al., Int. J. Mol. Sci., 17(11), 1938 (2016).

    Article  Google Scholar 

  31. I. B. Song, H. J. Gu, H. J. Han, et al., Appl. Biol. Chem., 61(4), 433 – 439 (2018).

    Article  CAS  Google Scholar 

  32. R. Ross and N. Engl. J. Med., 340(2), 115 – 126 (1999).

    Article  CAS  Google Scholar 

  33. A. J. Lusis, Nature, 407, 233 – 241 (2000).

    Article  CAS  Google Scholar 

  34. Y. V. Bobryshev, R. S. Lord, S. P. Rainer, et al., Acta. Histochem., 98(2), 185 – 194 (1996).

    Article  CAS  Google Scholar 

  35. K. D. O’Brien, T. O. McDonald, A. Chait, et al., Circulation, 93(4), 672 – 682 (1996).

    Article  Google Scholar 

Download references

Acknowledgments

RDA (Rural Development Administration, Korea) supported this study through “Cooperative Research Program for Agriculture Science & Technology Development” (Project No. PJ014204032019).

Author information

Authors and Affiliations

  1. Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Kyung Hee University, Yongin, 17104, Republic of Korea

    S. K. Choi, N. N. Thi, J. E. Kwon, Y. G. Lee, S. C. Kang & N. I. Baek

Authors
  1. S. K. Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. N. Thi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. E. Kwon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. G. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. C. Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. I. Baek
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. I. Baek.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Choi, S.K., Thi, N.N., Kwon, J.E. et al. Anti-Inflammatory Activity of Benzyl Glycosides from the Flowers of Lilium Asiatic Hybrids. Pharm Chem J 55, 170–175 (2021). https://doi.org/10.1007/s11094-021-02386-0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-021-02386-0

Keywords

Search

Navigation