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Complex Processing of Rhaponticum carthamoides Rhizomes with Roots to Produce Ecdisten Substance, Total Flavonoids, and Lipid Concentrate

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Pharmaceutical Chemistry Journal Aims and scope

Ecdisten waste-recycling processes were studied for rational use of the rhizomes with roots of Rhaponticum carthamoides. Separation of flavonoids from ecdysteroids over polyamide at 25:1 and 30:1 ratios of sorbent layer height to column diameter and a 1:8 ratio of material to sorbent were proposed. It was found that the crude product should be recrystallized from 70% EtOH at a product:solvent ratio of 1:30 and the aqueous EtOH solution of total flavonoids should be condensed to one third of the initial volume followed by storage in a crystallizer for at least 8 h to obtain substance containing at least 95% total flavonoids from the crude product. A complex processing technology for rhizomes with roots of R. carthamoides that could produce substance of the adaptogen ecdisten, substance of a hypoazotemic drug based on total flavonoids, and lipid concentrate for use in cosmetology was developed. A spectrophotometric method for quantitative determination at 353 ± 2 nm of total flavonoids recalculated as luteolin was proposed.

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Authors and Affiliations

  1. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 77 M. Ulugbeka St., Tashkent, Uzbekistan, 100170

    A. U. Mamatkhanov, R. M. Khalilov & M. A. Mamatkhanova

Authors
  1. A. U. Mamatkhanov
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  2. R. M. Khalilov
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  3. M. A. Mamatkhanova
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Correspondence to A. U. Mamatkhanov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 10, pp. 42 – 46, October, 2020.

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Mamatkhanov, A.U., Khalilov, R.M. & Mamatkhanova, M.A. Complex Processing of Rhaponticum carthamoides Rhizomes with Roots to Produce Ecdisten Substance, Total Flavonoids, and Lipid Concentrate. Pharm Chem J 54, 1040–1044 (2021). https://doi.org/10.1007/s11094-021-02325-z

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  • DOI: https://doi.org/10.1007/s11094-021-02325-z

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