Hetarylammonium 2-hydroxy-4-oxo-4-(thien-2-yl)but-2-enoates and 2-hydroxy-4-oxo-4-(thien-2-yl)but-2-enoic acid hetarylamides were obtained. Their biological activity was studied. Marginally toxic compounds with activities comparable to and exceeding those of reference compounds were discovered. Results of biological tests indicated the expediency of seeking hemostatic and anthelminthic agents in the series of hetarylammonium 2-hydroxy-4-oxo-4-(thien-2-yl)but-2-enoates. 2-Hydroxy-4-oxo-4-(thien-2-yl)but-2-enoic acid hetarylamides are promising candidates for developing new drugs possessing anti-inflammatory activity
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References
S. S. Kataev, N. V. Kutkovaya, R. R. Makhmudov, et al., Khim.-farm. Zh., 38(3), 16 – 18 (2004).
N. A. Pulina, V. V. Zalesov, V. V. Yushkov, et al., Vopr. Biol., Med. Farm. Khim., 2, 37 – 40 (2008).
N. A. Pulina, F. V. Sobin, A. I. Krasnova, et al., Khim.-farm. Zh., 45(5), 18 – 21 (2011).
N. A. Pulina, F. V. Sobin, B. Ya. Syropyatov, et al., Khim.-farm. Zh., 46(12), 15 – 18 (2012).
A. V. Starkova, B. Ya. Syropyatov, F. V. Sobin, et al., Eksp. Klin. Farmakol., 78(7), 12 – 14 (2015).
R. Mishra, K. K. Jha, S. Kumar, and I. Tomer, Pharma Chem., 3(4), 38 – 54 (2011).
O. N. Chupakhin, L. P. Sidorova, N. M. Perova, et al., Khim.-farm. Zh., 45(5), 12 – 17 (2011).
Yu. S. Logvinova, V. A. Makarov, O. N. Chupakhin, et al., Eksp. Klin. Farmakol., 76(2), 13 – 16 (2013).
S. Ali, N. Rasool, A. Ullah, et al., Molecules, 18(12), 14711 – 14725 (2013).
A. N. Mironov (ed.), Handbook for Preclinical Drug Trials [in Russian], Grif i K, Moscow (2012).
E. O. Ajaiyeoba and J. I. Okogun, Phytother. Res., 10, 436 – 437 (1996).
A. A. Yurasova, A. S. Makarova, and D. O. Skobelev, Toksikol. Vestn., No. 1 (106), 2 – 10 (2011).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 10, pp. 21 – 25, October, 2020.
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Sobin, F.V., Pulina, N.A., Lipatnikov, K.V. et al. Synthesis and Hemostatic, Anti-Inflammatory, and Anthelminthic Activity of 2-hydroxy-4-oxo-4-(thien-2-yl)but-2-enoic Acid Derivatives. Pharm Chem J 54, 1003–1007 (2021). https://doi.org/10.1007/s11094-021-02310-6
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DOI: https://doi.org/10.1007/s11094-021-02310-6