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The Role of a Dopaminergic Component in the Analgesic Effect of the Low-Affinity NMDA Receptor Antagonist Hemantane

  • MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

The role of dopaminergic transmission in the mechanism of analgesic action of the low-affinity NMDAreceptor antagonist hemantane [N-(2-adamantyl)hexamethyleneimine hydrochloride] was demonstrated experimentally. A single i.p. injection of hemantane at a dose of 20 mg/kg has the ability to inhibit dopamine reuptake and exhibits an analgesic effect in the somatic thermal pain model (tail-flick test) and visceral pain model (acetic-acid-induced writhing test) in ICR mice. The dopamine D1 receptor antagonist R(+)-SCH-23390 at a dose of 0.005 mg/kg and dopamine D2 receptor antagonist sulpiride at a dose of 5 mg/kg administered by a single i.p. injection 30 min before hemantane injection prevented manifestation of the antinociceptive activity of the NMDA receptor antagonist in the used methods, which was more pronounced for the spinal reflex (tail-flick test).

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Acknowledgments

The work was performed in the framework of a State Task on topic No. 0521-2019-0007.

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Authors and Affiliations

  1. V. V. Zakusov State Institute of Pharmacology, 8 Baltiiskaya St, Moscow, 125315, Russia

    E. A. Ivanova, I. G. Kapitsa & T. A. Voronina

Authors
  1. E. A. Ivanova
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  2. I. G. Kapitsa
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  3. T. A. Voronina
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Correspondence to E. A. Ivanova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 10, pp. 2 – 6, October, 2020.

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Ivanova, E.A., Kapitsa, I.G. & Voronina, T.A. The Role of a Dopaminergic Component in the Analgesic Effect of the Low-Affinity NMDA Receptor Antagonist Hemantane. Pharm Chem J 54, 985–988 (2021). https://doi.org/10.1007/s11094-021-02307-1

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  • DOI: https://doi.org/10.1007/s11094-021-02307-1

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