It was established that roots of Ammothamnus lehmannii should be extracted with EtOH (90%) at room temperature at least five times for effective extraction of total flavonoids from them. At least five extractions with BuOH of the bottom residue of the A. lehmannii extract were necessary for almost complete extraction of total flavonoids from it. Conditions for isolation of flavonoids were determined and included dissolution of the crude product in alkaline solution (3%) followed by acidification to pH 5.0 – 7.0. A technological scheme for isolation of a drug composition consisting of total flavonoids from A. lehmannii roots was developed. Aspectrophotometric method for quantitative determination of the resulting total flavonoids was proposed. Total flavonoids isolated from A. lehmannii roots had a pronounced anthelmintic effect with anticestodal activity exceeding that of the pure flavonoid ammothamnidine and could be recommended as a potential effective antiparasitic drug.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 9, pp. 37 – 42, September, 2020.
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Mamatkhanova, M.A., Islamova, Z.I., Khalilov, R.M. et al. Production Technology of an Anthelmintic Drug from Ammothamnus Lehmannii Roots. Pharm Chem J 54, 932–937 (2020). https://doi.org/10.1007/s11094-020-02299-4
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DOI: https://doi.org/10.1007/s11094-020-02299-4