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Generative Function of Female Rats Upon Intragastric Administration of Tablets of the New Steroid Drug Gestobutanoil

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The generative function of female rats upon intragastric administration of tablets of gestobutanoil at doses of 0.25 and 2.5 mg/kg (calculated doses corresponding to the therapeutic dose and ten times higher) was studied. Gestobutanoil was administered two weeks before pregnancy, which corresponded to 2 – 3 estrous cycles. Gestobutanoil at a dose of 0.25 mg/kg exhibited progestogen activity. The duration of estrus, the fertility index, and the numbers of pregnancy corpus lutea and live fetuses increased in female rats. Administration of gestobutanoil at a dose of 2.5 mg/kg produced a contraceptive effect that manifested as a prolonged estrous cycle and a reduction of fertility and numbers of corpus lutea and fetuses. Gestobutanoil at both doses did not produce a teratogenic effect and did not affect the vitality of F1 offspring (survival, body-weight dynamics, sensory-motor behavior development).

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References

  1. M. Roosli, P. Frei, et al., Bull. W. H. O., 88(12), 877 – 953 (2010).

    Article  Google Scholar 

  2. M. V. Maiorov, Med. Farm., 2(5), 8 – 14 (1999).

    Google Scholar 

  3. M. V. Maiorov, Modern Methods of Contraception. Line of Health [in Russian], Farmitek, Kharkov (2005), pp. 20 – 31.

  4. P. V. Sergeev, T. A. Fedotcheva, V. M. Rzheznikov, et al., Vestn. Ross. Akad. Med. Nauk, 5, 27 – 32 (2007).

    Google Scholar 

  5. A. V. Semeikin, T. A. Fedotcheva, I. S. Levina, et al., Khim.-farm. Zh., 48, 9 – 13 (2014).

  6. T. A. Nazarenko, N. A. Zyryaeva, and M. U. Magamadova, Probl. Reprod., 19(2), 20 – 25 (2013).

    Google Scholar 

  7. M. Manno, E. Marchesan, D. Cicutto, et al., Int. J. Fertil. Steril., 83(5), 1391 – 1396 (2005).

    Article  CAS  Google Scholar 

  8. T. A. Fedotcheva and N. L. Shimanovskii, Probl. Endokrinol., 64(1), 54 – 61 (2018); https://doi.org/10.14341/probl201864154 – 61.

  9. E. S. Stepanova, L. M. Makarenkova, V. V. Chistyakov, et al., Khim.-farm. Zh., 52(12), 55 – 59 (2018); https://doi.org/10.1007/s11094-019-01944-x; E. S. Stepanova, L. M. Makarenkova, V. V. Chistyakov, et al., Pharm. Chem. J., 52(12), 1016 – 1020 (2019); https://doi.org/10.30906/0023-1134-2018-52-12-55-59.

  10. T. A. Fedotcheva, A. G. Kruglov, V. V. Teplova, et al., Biofizika, 57(6), 1014 – 1019 (2012); T. A. Fedotcheva, N. L. Shimanovskii, A. G. Kruglov, et al., Biophysics, 57(6), 792 – 795 (2012); https://doi.org/10.1134/S0006350912060061.

  11. H. A. van Dipen, Reprod. Biol. Endocrinol., 10, 85 (2012); https://doi.org/10.1186/1477-7827-10-85.

    Article  CAS  Google Scholar 

  12. N. I. Sheina, V. A. Parshin, Yu. L. Rybakov, et al., Eksp. Klin. Farmakol., 81, No. 11, 55 – 62 (2018); https://doi.org/10.30906/0869-2092-2018-81-11-18-25.

  13. N. L. Shimanovskii, T. A. Fedotcheva, et al., RU Pat. No. 2,684,917, Apr. 16, 2019.

  14. A. P. Dyban, Early Development of Mammals [in Russian], Nauka, Leningrad (1988).

  15. E. Menegola, M. L. Broccia, and E. Giavini, Teratology, 64(3), 125 – 133 (2001).

    Article  CAS  Google Scholar 

  16. D. Neubert, Teratog., Carcinog., Mutagen., 22(3), 159 – 174 (2002).

    Article  CAS  Google Scholar 

  17. A. N. Mironov (ed.), Handbook for Preclinical Drug Trials [in Russian], Part 1, Grif i K, Moscow (2012).

  18. T. A. Gus’kova, Toksikol. Vestn., No. 5, 2 – 6 (2010).

  19. O. A. Zeinalov, V. A. Andryushina, and D. A. Avdanina, Ross. Vet. Zh., No. 1, 16 – 19 (2005).

  20. O. A. Zeinalov, T. S. Savinova, and V. A. Andryushina, Ross. Vet. Zh., No. 2, 33 – 35 (2017).

  21. C. L. Chaffin and C. A. VandeVoort, Exp. Biol. Med. (Maywood), 238(5), 539 – 548 (2013).

    Article  Google Scholar 

  22. L. J. Webber, S. Stubbs, J. Stark, et al., Lancet, 362(9389), 1017 – 1021 (2003).

    Article  CAS  Google Scholar 

  23. N. I. Tapil’skaya, M. A. Petrosyan, and E. A. Lesik, Eksp. Klin. Farmakol., 65(1), 44 – 45 (2002).

    Google Scholar 

  24. V. V. Korkhov and N. I. Tapil’skaya, Gestagens in Obstetrics-Gynecological Practice. Physicians Guide [in Russian], Spets-Lit, St. Petersburg (2005).

  25. J. L. Shardein, R. Birch, R. Hesley, et al., Birth Defects Res., Part B, 95(2), 160 – 170 (2012).

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Acknowledgments

The work was sponsored by RFBR Grant No. 19-015-00195/19.

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Authors and Affiliations

  1. N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, 119435, Russia

    N. I. Sheina, V. A. Parshin, V. V. Kolesnikova, L. I. Myalina, L. P. Sazonova, T. A. Fedotcheva & N. L. Shimanovskii

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  1. N. I. Sheina
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  2. V. A. Parshin
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  3. V. V. Kolesnikova
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  4. L. I. Myalina
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  5. L. P. Sazonova
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  6. T. A. Fedotcheva
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  7. N. L. Shimanovskii
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Correspondence to N. I. Sheina.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 5, pp. 11 – 15, May, 2020.

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Sheina, N.I., Parshin, V.A., Kolesnikova, V.V. et al. Generative Function of Female Rats Upon Intragastric Administration of Tablets of the New Steroid Drug Gestobutanoil. Pharm Chem J 54, 439–443 (2020). https://doi.org/10.1007/s11094-020-02219-6

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  • DOI: https://doi.org/10.1007/s11094-020-02219-6

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