The influence of the dimeric dipeptide mimetic of brain-derived neurotrophic factor (BDNF) bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106, dosage form) during three-day peroral administration at a dose of 0.1 mg/kg on the 1% sucrose solution preference test and the content of postsynaptic density protein (PSD-95) in the prefrontal cortex and hippocampus of C57Bl/6 mice was studied in an acute three-day social defeat stress model. The preference for sucrose solution decreased and the PSD-95 content in the prefrontal cortex was halved statistically significantly in stressed mice as compared to control animals. The hippocampal PSD-95 content in stressed animals did not change. Anhedonia was completely prevented after each stress session according to the sucrose preference test with peroral administration of GSB-106 at a dose of 0.1 mg/kg once per day for three days. GSB-106 did not reduce the prefrontal PSD-95 content of stressed animals during the experiment.
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The work was performed in the framework of a State Task for 2019 – 2021 on topics No. 0521-2019-0003 “Search for pharmacological methods for selective activation of signaling pathways of tyrosine-kinase neurotrophin receptors as platforms for creating drugs free of the side effects of native neurotrophins” and No. 0521-2019-0002 “Development of new agents and methods for pharmacotherapy of anxiety and depression.”
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 5, pp. 3 – 6, May, 2020.
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Tallerova, A.V., Mezhlumyan, A.G., Povarnina, P.Y. et al. GSB-106 Dipeptide Mimetic of Brain-Derived Neurotrophic Factor Prevents Anhedonia Development under Acute Social Defeat Stress Conditions in Mice. Pharm Chem J 54, 431–434 (2020). https://doi.org/10.1007/s11094-020-02217-8
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DOI: https://doi.org/10.1007/s11094-020-02217-8