Skip to main content
SpringerLink
Log in

Development and Validation of a Gas Chromatographic Method for Quantitative Determination of the Active Ingredient in Phenyl Salicylate Drug Substance

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Anew method for quantitative determination of the active ingredient in phenyl salicylate drug substance using gas chromatography with flame-ionization detection (GC-FID) was developed and validated. The experiments used an HP-5 quartz capillary column with a grafted stationary phase of diphenyl- (5%) and dimethylpolysiloxane (95%) (Agilent Technologies, USA). The conditions for the chromatographic separation and the chromatography system suitability parameters were determined. The phenyl salicylate content in the drug substance was determined by the internal standard method. The method was validated for specificity, linearity, precision, and stability (robustness) and was found to meet the main acceptance criteria.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. State Pharmacopoeia of the USSR, Xth Ed., Meditsina, Moscow (1968), pp. 530 – 531.

  2. State Pharmacopoeia of the RF, XIIIth Ed., Moscow (2015), Vol. 1, pp. 490 – 495.

  3. State Pharmacopoeia of the RF, XIIIth Ed., Moscow (2015), Vol. 1, pp. 447 – 474.

  4. State Pharmacopoeia of the RF, XIIIth Ed., Moscow (2015), Vol. 1, pp. 121 – 129.

  5. J. Krzek, J. S. Czekaj, and W. Rzeszutko, Acta Pol. Pharm., 60(5), 343 – 349 (2003).

    CAS  PubMed  Google Scholar 

  6. K. Mori, K. Terajima, Y. Nakamura, et al., J. Tokyo-toritsu Eisei Kenkyusho Kenkyu Nenpo, 53, 65 – 67 (2003).

  7. State Pharmacopoeia of the RF, XIIIth Ed., Moscow (2015), Vol. 1, pp. 235 – 264.

  8. State Pharmacopoeia of the RF, XIIIth Ed., Moscow (2015), Vol. 1, pp. 222 – 234.

Download references

Author information

Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Special Structural Subdivision of Kazan Federal Research Center, Russian Academy of Sciences, Kazan, Tatarstan, 420088, Russia

    O. V. Kupriyanova & V. A. Milyukov

  2. Kazan State Medical University, Ministry of Health of the RF, Kazan, Tatarstan, 420012, Russia

    O. V. Kupriyanova, R. G. Sadykova & R. I. Mustafin

  3. B. N. Yeltsin Ural Federal University, Ekaterinburg, 620002, Russia

    V. A. Shevyrin

Authors
  1. O. V. Kupriyanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. A. Milyukov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. A. Shevyrin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. G. Sadykova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. I. Mustafin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O. V. Kupriyanova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 1, pp. 43 – 48, January, 2020.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kupriyanova, O.V., Milyukov, V.A., Shevyrin, V.A. et al. Development and Validation of a Gas Chromatographic Method for Quantitative Determination of the Active Ingredient in Phenyl Salicylate Drug Substance. Pharm Chem J 54, 73–78 (2020). https://doi.org/10.1007/s11094-020-02159-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-020-02159-1

Keywords

Search

Navigation