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Development and Validation of a Method for Determining Lidocaine Hydrochloride and Miramistin in an Innovative Wound-Healing Gel

  • STRUCTURE OF CHEMICAL COMPOUNDS, METHODS OF ANALYSIS AND PROCESS CONTROL
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  • volume 54, pages 69–72 (2020)
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An HPLC-UV method for quantitative determination of lidocaine and miramistin in a combination wound-healing gel is reported. The method was validated for specificity, linearity, accuracy, and precision. The linear range for lidocaine hydrochloride was 0.08 – 0.12 mg/mL; for miramistin, 0.04 – 0.06 mg/mL. The linear correlation coefficients were 0.9992 and 0.9996 for lidocaine hydrochloride and miramistin, respectively. The method could be used for quantitative evaluation of lidocaine and miramistin in combination medicines.

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Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the RF (Sechenov University), Moscow, 119991, Russia

    L. L. Brkich, P. A. Markin, N. E. Moskaleva, N. V. Pyatigorskaya & G. E. Brkich

  2. MIREA – Russian Technological University (RTU MIREA), Moscow, 119454, Russia

    A. V. Panov & M. A. Grin

Authors
  1. L. L. Brkich
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  2. P. A. Markin
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  3. N. E. Moskaleva
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  4. N. V. Pyatigorskaya
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  5. G. E. Brkich
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  6. A. V. Panov
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  7. M. A. Grin
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Correspondence to L. L. Brkich.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 1, pp. 38 – 42, January, 2020.

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Brkich, L.L., Markin, P.A., Moskaleva, N.E. et al. Development and Validation of a Method for Determining Lidocaine Hydrochloride and Miramistin in an Innovative Wound-Healing Gel. Pharm Chem J 54, 69–72 (2020). https://doi.org/10.1007/s11094-020-02158-2

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  • DOI: https://doi.org/10.1007/s11094-020-02158-2

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