Radioprotective Efficiency of Recombinant Flagellin and Interleukin-1 Beta with Combined Administration

The radioprotective efficacy of recombinant flagellin (FL) and interleukin-1 beta (IL-1) administered in combinations for preventive or therapeutic purposes was studied in experiments on white mongrel mice. The drugs were administered i.p. at doses of 1 mg/kg (FL) and 50 μg/kg (IL-1β). Simultaneous administration of the drugs in the early stages before irradiation was shown to be most efficacious in terms of 30-day survival of mice exposed to x-rays at a dose of 7.5 Gy (100% survival of mice vs. 53% survival in the control group, p < 0.01). Sequential administration of FL before exposure and IL-1β after exposure increased survival of the mice by 40% (p < 0.05). The results indicated that combined use of biotechnological drugs for radioprotection was promising.

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Correspondence to E. V. Murzina.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 10, pp. 18 – 21, October, 2018.

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Murzina, E.V., Sofronov, G.A., Simbirtsev, A.S. et al. Radioprotective Efficiency of Recombinant Flagellin and Interleukin-1 Beta with Combined Administration. Pharm Chem J 52, 835–838 (2019). https://doi.org/10.1007/s11094-019-1910-1

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Keywords

  • flagellin
  • combined use
  • interleukin-1 beta
  • exposure
  • survival