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Preparation and Properties of Lysozyme-Containing Eye Drops for Tear-Substitutive Therapy

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Pharmaceutical Chemistry Journal Aims and scope

Lysozyme incorporated in polymer solutions is shown to be stabilized during prolonged storage at low temperatures (0 – 4°C) for 12 months with 96% preservation of the hydrolytic activity. Variations of the pH and temperature activity profiles of the enzyme incorporated in polymer solutions promotes its activation under physiological conditions during acidosis associated with inflammations of various etiologies and upon development of dry eye syndrome. Investigation of the biochemical and physicochemical properties of a lysozyme-containing solution showed that the developed eye drops met requirements applicable to them (density, viscosity, osmolality, refractive index, sterility). Ophthalmic safety studies showed that the solution was non-allergenic.

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Authors and Affiliations

  1. A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, 65080, Ukraine

    I. I. Romanovskaya & S. S. Dekina

  2. V. P. Filatov Institute of Eye Diseases and Tissue Therapy, National Academy of Medical Sciences of Ukraine, Odessa, 65000, Ukraine

    E. P. Sotnikova & A. B. Abramova

Authors
  1. I. I. Romanovskaya
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  2. S. S. Dekina
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  3. E. P. Sotnikova
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  4. A. B. Abramova
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Corresponding author

Correspondence to I. I. Romanovskaya.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 8, pp. 41 – 44, August, 2019.

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Romanovskaya, I.I., Dekina, S.S., Sotnikova, E.P. et al. Preparation and Properties of Lysozyme-Containing Eye Drops for Tear-Substitutive Therapy. Pharm Chem J 53, 755–758 (2019). https://doi.org/10.1007/s11094-019-02074-0

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  • DOI: https://doi.org/10.1007/s11094-019-02074-0

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