Second-generation antipsychotic substances, as compared with first-generation antipsychotics, are more effective in relation to psychotic symptoms and have significantly lower potential for developing extrapyramidal impairments such as parkinsonism and late dyskinesia. However, use of these agents is associated with significant weight gain in patients. Advances in the pharmacogenetics of antipsychotic-induced weight gain are analyzed here.
Similar content being viewed by others
References
P. R. Gavin and O. O. McGowan, J. Psychopharmacol., 31(11), 1430 – 1436 (2017).
M. De Hert, J. M. Dekker, D. Wood, et al., Eur. Psychiatry, 24, 412 – 424 (2009).
S. J. Cooper, G. P. Reynolds, T. Barnes, et al., J. Psychopharmacol., 30, 717 – 748 (2016).
R. H. Liu, M. Mizuta, and S. Matsukura., Eur. J. Pharmacol., 458(1 – 2), 227 – 233 (2003).
K. K. Harris, M. Zope, and T. C. Friedman., Nat. Rev. Endocrinol., 12(5), 299 – 308 (2016).
E. M. Denisov, Zh. Psikhiatrii Med. Psikhol., No. 1 – 2 (24 – 25), 151 – 160 (2010).
D. J. Müller and J. L. Kennedy, Pharmacogenomics, 7(6), 863 – 887 (2006).
C. Rummel-Kluge, K. Komossa, S. Schwarz, et al., Schizophr. Res., 123, 225 – 233 (2010).
S. Leucht, A. Cipriani, L. Spineli, et al., Lancet, 382, 951 – 962 (2013).
A. J. Risselada, H. Mulder, and R. Eibert, Pharmacogenomics, 12(8), 1213 – 1227 (2011).
K. Vasudev, Can. J. Psychiatry, 62(2), 138 – 149 (2017).
R. R. MacNeil and D. J. Müller, Molecular. Neuropsychiatry, 2(2), 61 – 78 (2016).
S. Gebhardt, F. M. Theisen, M. Haberhausen, et al., J. Clin. Pharm. Ther., 35, 207 – 211 (2010).
S. Kapur and D. Mamo, Prog. Neuro-Psychoph., 27, No. 7, 1081 – 1090 (2003).
A. A. Verhaegen and L. F. Van Gaal, J. Endocrinol. Invest., 40, No. 11, 1165 – 1174 (2017).
T. A. P. Lett, T. J. M. Wallace, and N. I. Chowdhury, Molec. Psychiatry, 17, 242 – 266 (2012).
Z. Jian-Ping and K. Anil, Expert. Opin. Drug Metab. Toxicol., 7, No. 1, 9 – 37 (2011).
V. S. Basile, M. Masellis, R. S McIntyre, et al., J. Clin. Psychiatry, 62(S23), 45 – 66 (2001).
L. Tecott, L. Sun, S. F. Akana, et al., Nature, 374, 542 – 546 (1995).
M. N. Sicard, C. C. Zai, A. K. Tiwari, et al. Pharmacogenomics, 11, 1561 – 1571 (2010).
H. Y. Lane, Y. C. Liu, and C. L. Huang, J. Clin. Psychopharmacol., 26, 128 – 134 (2006).
D. A. Wirshing, W. C. Wirshing, L. Kysar, et al., J. Clin. Psychiatry, 60, 358 – 363 (1999).
Postgenomic and Nanotechnology Innovations (2003 – 2014) [in Russian], [Online resource] URL: http: // xn–h1aaoah. xn–p1ai / information / genes-information / 145.html (date accessed August 24, 2018).
X. Y. Zhang, Y. L. Tan, D. F. Zhou, et al., J. Clin. Psychopharmacol., 27, 246 – 251 (2007).
C. A. Calarge, V. L. Ellingrod, B. Zimmerman, et al., Psychiatric Gen., 19, 320 – 327 (2009).
O. O. Yevtushenko, S. J. Cooper, R. O’Neill, et al., Br. J. Psychiatry, 192, 424 – 428 (2008).
A. K. Malhotra, C. U. Correll, N. I. Chowdhury, et al., Arch. Gen. Psychiatry, 69(9), 904 – 912 (2012).
F. Czerwensky, S. Leucht, and W. Steimer, J. Clin. Psychopharmacol., 33, 74 – 79 (2013).
N. I. Chowdhury, A. K. Tiwari, R. P. Souza, et al., Pharmacogenomics J., 13(3), 272 – 279 (2013).
A. K. Tiwari, E. J. Brandl, and C. C. Zai, World J. Biol. Psychiatry, 17(3), 221 – 229 (2016).
C. C. Zai, A. K. Tiwari, and G. C. Zai, Cur. Opin. Psychiatry, 31(3), 200 – 212 (2018).
C. Bousman, J. Allen, and H. A. Eyre, Am. J. Psychiatry, 175, 189 (2018).
S. H. Preskorn, J. Psychiatr. Pract., 19, 397 – 405 (2013).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol, 53, No, 7, pp, 59 – 62, July, 2019.
Rights and permissions
About this article
Cite this article
Zhuravleva, E.O., Vel’ts, N.Y., Snegireva, I.I. et al. Pharmacogenetic Tests for Antipsychotic-Induced Weight Gain. Pharm Chem J 53, 668–671 (2019). https://doi.org/10.1007/s11094-019-02059-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-019-02059-z