Skip to main content
SpringerLink
Log in

Synthesis and Cytotoxic Activity of Hydroxy-Substituted Glaucocalyxin A

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Six new glaucocalyxin A derivatives were synthesized by hydroxy substitution, their structures were elucidated on the basis of spectral analysis, and cytotoxic activity was tested by MTT method. Not all of the obtained glaucocalyxin A derivatives have their cytotoxicity enhanced as a result of this substitution. Moreover, the hydroxy substitution did not increase the cytotoxicity of glaucocalyxin A significantly. Other glaucocalyxin A derivatives should be obtained by skeleton modification to find compounds with significant cytotoxicity for research and development of new antitumor drugs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.

Similar content being viewed by others

References

  1. Y. L. Xu, X. C. Sun, H. D. Sun, et al., Acta Bot. Yunn., 3(3), 283 – 286 (1981).

    CAS  Google Scholar 

  2. Z. B. Xiang, X. Y. Liu, and X. H. Li. Pharm. Chem. J., 48(12), 806 – 816 (2015).

    Article  Google Scholar 

  3. H. L. Jiang, M. Zhu, Y. Chen, et al., Chin. Trad. Pat. Med., 35(1), 86 – 89 (2013).

    Google Scholar 

  4. Z. B. Xiang, X. L. Wu, X. Y. Liu, et al., Nat. Prod. Res., 28(24), 2221 – 2236 (2014).

    Article  CAS  Google Scholar 

  5. S. Y. Yao, T. Liu, R. Liu, et al., J. Chongqing Technol. Business Univ. (Nat. Sci. Ed.), 31(12), 86 – 91 (2014).

  6. C. J. Liu, Z. H. Zhao, Q. L. Wang, et al., Acta Bot. Yunn., 10(4), 471 – 474 (1988).

    CAS  Google Scholar 

  7. J. Y. Xu, J. Y. Yang, Q. Ran, et al., Bioorg. Med. Chem. Lett., 18, 4741 – 4744 (2008).

    Article  CAS  Google Scholar 

  8. F. Huang, F. Q. Qu, X. Q. Ren, et al., J. Chongqing Technol. Business Univ. (Nat. Sci. Ed.), 32(1), 33 – 37 (2015).

  9. Z. B. Xiang, Y. X. Xu, Y. S. Jin, et al., Asian J. Chem., 21(4), 2721 – 2725 (2009).

    CAS  Google Scholar 

  10. Z. B. Xiang, X. Shen, Y. Tang, et al., Asian J. Chem., 23(8), 3761 – 3762 (2011).

    CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the Key Projects of Basic Science and Advanced Technology Research of Chongqing City (cstc2015jcyjBX0125) and Scientific Research Foundation of Chongqing Technology and Business University (2015-56-07).

Author information

Authors and Affiliations

  1. College of Environment and Resources, Chongqing Technology and Business University, Chongqing, 400067, China

    Zhaobao Xiang

  2. Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing Technology and Business University, Chongqing, 400067, China

    Zhaobao Xiang & Xuxu Zheng

  3. Academic Quality Inspection and Evaluation Office, Chongqing Technology and Business University, Chongqing, 400067, China

    Xiaoling Wu

Authors
  1. Zhaobao Xiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaoling Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xuxu Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zhaobao Xiang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xiang, Z., Wu, X. & Zheng, X. Synthesis and Cytotoxic Activity of Hydroxy-Substituted Glaucocalyxin A. Pharm Chem J 53, 535–538 (2019). https://doi.org/10.1007/s11094-019-02033-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-019-02033-9

Keywords

Search

Navigation