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Influence of Filipendula ulmaria (L.) Maxim. Extract on Lewis Lung Carcinoma Development and Cytostatic Therapy Effectiveness in Mice

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Pharmaceutical Chemistry Journal Aims and scope

Meadowsweet extract was prepared by heating the aerial part of Filipendula ulmaria (L.) Maxim. in EtOH (70%). Experiments in C57BL/6 mice with Lewis lung carcinoma (LLC) showed that the extract at doses of 50 and 100 mg/kg exhibited dose-dependent antimetastatic action. Combined treatment of animals with LLC using cyclophosphamide and meadowsweet extract at doses of 50 and 100 mg/kg increased the antitumor effect of the cytostatic drug.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 3 Prosp. Lenina, Tomsk, 634028, Russia

    E. N. Amosova, I. V. Shilova, E. P. Zueva & O. Yu. Rybalkina

Authors
  1. E. N. Amosova
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  2. I. V. Shilova
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  3. E. P. Zueva
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  4. O. Yu. Rybalkina
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Corresponding author

Correspondence to E. N. Amosova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 5, pp. 36 – 39, May, 2019.

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Amosova, E.N., Shilova, I.V., Zueva, E.P. et al. Influence of Filipendula ulmaria (L.) Maxim. Extract on Lewis Lung Carcinoma Development and Cytostatic Therapy Effectiveness in Mice. Pharm Chem J 53, 458–461 (2019). https://doi.org/10.1007/s11094-019-02019-7

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  • DOI: https://doi.org/10.1007/s11094-019-02019-7

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