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Pharmaceutical Chemistry Journal

, Volume 53, Issue 3, pp 212–215 | Cite as

Synthesis and Pharmacological Properties of N-Decyltropine (IEM-1556) as Compared to Selective Nicotinic Receptor Antagonist Tert-Butyldecylammonium (IEM-1678)

  • V. E. GmiroEmail author
  • S. E. Serdyuk
Article
  • 2 Downloads

The property profile of N-decyltropine (IEM-1556) has significant advantages over that of its prototype, the selective nicotinic receptor antagonist tert-butyldecylammonium (IEM-1678), because its anticonvulsant, antiparkinsonian, antidepressant, and analgesic activities are significantly greater and its therapeutic index is 2.8 times higher than that of IEM-1678. The higher pharmacological activity and lower toxicity of IEM-1556 are explained by the fact that IEM-1556 not only blocks nicotinic receptors but also stimulates subdiaphragmatic vagal afferents.

Keywords

N-decyltropine IEM-1556 IEM-1678 nicotinic receptor vagus therapeutic index 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute of Experimental MedicineSt. PetersburgRussia

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