Piperazine rings are important heterocyclic targets in organic synthesis and are useful synthetic intermediates or intricate parts of biologically active molecules. In our efforts, a series of piperazine derivatives has been prepared discovering new classes of antimicrobial agents, including bis(phthalimido)piperazine, bis(3-aminopropyl) piperazine, 2,3-dihydro-phthalazine-1,4-dione, and bis(3,4-aminophenol)piperazine. The synthesized antimicrobial agents have been studied using various spectroscopic techniques. Furthermore, these compounds have been screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. Three compounds exhibited mild to good antibacterial activity, but somewhat lower antifungal activity against tested microbial strains.
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14 May 2019
There is an error in the order of the author names.
The correct order should be: Muhammad Azhar Abbas,<Superscript>2</Superscript> Afeefa Aslam,<Superscript>1</Superscript> Mudassir Iqbal,<Superscript>3,*</Superscript> Sajid Bashir,<Superscript>3</Superscript> Tahir Mehmood,<Superscript>4</Superscript> and Joerg Kressler<Superscript>5</Superscript>
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Acknowledgments
The authors would like to thank the Vice Chancellor of the University of Sargodha and Prof. J. Kressler (Institute fur Chemie, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany) for their moral and excellent technical support regarding this work.
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Aslam, A., Abbas, M.A., Iqbal, M. et al. Synthesis, Characterization and Antimicrobial Activity of Bis(Phthalimido)Piperazine and its Derivatives: a New Class of Bioactive Molecules with Enhanced Safety and Efficacy. Pharm Chem J 53, 43–47 (2019). https://doi.org/10.1007/s11094-019-01953-w
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DOI: https://doi.org/10.1007/s11094-019-01953-w