Advertisement

Pharmaceutical Chemistry Journal

, Volume 53, Issue 1, pp 40–42 | Cite as

Assessment of the Acute Toxicity and Analgesic Activity of Ethyl-6-Amino-4-Aryl-5-Cyano-2,4-Dihydropyrano-2,3-C]-Pyrazole-3-Carboxylates

  • O. N. Gein
  • T. M. Zamaraeva
  • V. L. GeinEmail author
Article
  • 34 Downloads

The acute toxicity and analgesic activity of compounds of the ethyl-6-amino-4-aryl-5-cyano-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylate series were investigated. Study compounds were found to be essentially nontoxic and to have analgesic activity.

Keywords

pyranopyrazoles ethyl-6-amino-4-aryl-5-cyano-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates acute toxicity analgesic activity 

References

  1. 1.
    V. L. Gein, T. M. Zamaraeva, N. A. Buzmakova, et al., Khim.-Farm. Zh., 49(8), 18 – 20 (2015); Pharm. Chem. J., 49(8), 512 – 514 (2015).Google Scholar
  2. 2.
    E. N. El-Tamany, F. A. El-Shahed, and B. H. Mohamed, J. Serb. Chem. Soc., 64, 9 (1999).Google Scholar
  3. 3.
    A. Feurer, J. Luithle, S. Wirtz, G. Koenig, et al., (Bayer Healthcare AG, Germany), WO 2004009589; Chem. Abstr., 140, 146157 (2004).Google Scholar
  4. 4.
    A. M. Shestopalov, A. A. Shestopalov, and L. A. Rodinovskaya, Synthesis, 1, 1 – 25 (2008).CrossRefGoogle Scholar
  5. 5.
    L. A. Rodinovskaya, A. M. Shestopalov, A. Gromova, et al., Synthesis, 14, 2357 – 2370 (2006).Google Scholar
  6. 6.
    Suman Pal, et al., Tetrahedron Let., 54, 5434 – 5440 (2013).CrossRefGoogle Scholar
  7. 7.
    J. L. Wang, D. Liu, Z. J. Zhang, S. Shan, et al., Proc. Natl. Acad. Sci. U. S. A., 97, 7124 (2000).Google Scholar
  8. 8.
    M. R. Nadia, Y. K. Nahed, A. Fahmyb, and A. A. F. Ei-Sayeda, Pharm. Chem. J., 2, 400 (2010).Google Scholar
  9. 9.
    V. L. Gein, T. M. Zamaraeva, and P. A. Slepukhin, Tetrahedron Let., 55, 4525 – 4528 (2014).CrossRefGoogle Scholar
  10. 10.
    Guidelines for Preclinical Studies of Medicines [in Russian], A. N. Mironov (ed.), Grif i K, Moscow (2012).Google Scholar
  11. 11.
    V. V. Prozorovskii, M. P. Prozorovskaya, and V. M. Demchenko, Farmakol. Toksikol., 41(4), 497 – 502 (1978).Google Scholar
  12. 12.
    Guidelines for Experimental (Preclinical) Studies of Novel Pharmacological Substances [in Russian], Meditsina, Moscow (2005).Google Scholar
  13. 13.
    V. L. Gein, O. V. Bobrovskaya, G. V. Seliverstov, et al., Khim.-Farm. Zh., 51(3), 25 – 28 (2017); Pharm. Chem. J., 51(3), 187 – 190 (2017).Google Scholar
  14. 14.
    K. K. Sidorov, Farmakol. November. Promyshl. Khim. Veshch., 13, 47 – 51 (1973).Google Scholar
  15. 15.
    A. V. Piskarev, V. S. Nesterenko, and S. I. Suminov, Farmakol. Toksikol., No. 1, 48 – 54 (1973).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Perm State Pharmaceutical AcademyMinistry of Health of the Russian FederationPermRussia

Personalised recommendations