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Pharmaceutical Chemistry Journal

, Volume 52, Issue 12, pp 1007–1010 | Cite as

Joint Mechanical Processing of a Drug Substance with Enterosorbent

  • N. S. IvanovaEmail author
  • T. S. Pak
  • É. L. Kristalovich
  • D. B. Takhtaganova
Article
  • 29 Downloads

A selective enterosorbent (ES) based on natural silk fibroin with detoxification properties superior to those of traditional carbon sorbents (SKN-2K, SKN-4M) was proposed. The ES could be used as a matrix for drugs and a platform for new dosage forms to enhance the sanitizing effect of the proposed ES. Inclusion complexes of the ES with benzimidazolyl-2-methylcarbamate hydrochloride (I) were obtained and investigated. H-bonds were shown to form during the reaction of ES with I.

Keywords

enterosorbent mechanical activation benzimidazol-2-ylmethylcarbamate hydrochloride inclusion complexes difference spectrum supramolecular structure 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • N. S. Ivanova
    • 1
    Email author
  • T. S. Pak
    • 1
  • É. L. Kristalovich
    • 2
  • D. B. Takhtaganova
    • 2
  1. 1.Pskov State UniversityPskovRussia
  2. 2.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussia

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