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Pharmaceutical Chemistry Journal

, Volume 52, Issue 12, pp 996–1000 | Cite as

Development of the Optimal Diphilic Emulsion Compositions for Phytoextract Suppositories

  • V. G. SalovaEmail author
  • Zh. M. Kozlova
  • E. B. Odintsova
DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
  • 15 Downloads

Six compositions with various quantities of lipophilic and hydrophilic phases and different emulsifiers were developed. The suppository lipophilic component was type A solid fat; hydrophilic, poly (ethylene glycol) molecules with varying chain lengths and molecular masses. Comprehensive theoretical and experimental results led to formulation of the optimal composition with 35% marigold CO2 extract. The processing parameters for producing such suppositories were optimized.

Keywords

suppositories marigold extract diphilic suppository bases Dissolution test 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • V. G. Salova
    • 1
    Email author
  • Zh. M. Kozlova
    • 1
  • E. B. Odintsova
    • 1
  1. 1.I. M. Sechenov First Moscow State Medical University (Sechenov University)Ministry of Health of the Russian FederationMoscowRussia

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