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Development of a Quantitative Spectrophotometric Determination Method for Papaverine in Medicinal Preparations

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Pharmaceutical Chemistry Journal Aims and scope

A quantitative spectrophotometric determination method for papaverine in medicinal preparations based on formation of a colored ionic associate of papaverine, Ti(IV), and bromopyrogallol red (BPR) was developed. The conditions for forming {[TiO(H2R)2]2– · 2PP+} were determined. Addition of papaverine to a solution of anionic Ti-BPR caused a bathochromic shift to 640 nm with a simultaneous intensity gain. The molar absorption coefficient (ε = 8,800) indicated that the reaction was rather sensitive. The specificity of the reaction for papaverine enabled it to be determined without separating excipients. The method was highly sensitive, simple to perform, and adaptable to scale up. Toxic reagents were not required. The results had good precision (Sr = 0.007 – 0.02) and accuracy.

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Authors and Affiliations

  1. Dagestan State University, 43A Gadzhiyev St., Makhachkala, Dagestan, 367000, Russia

    Kh. A. Mirzaeva

  2. Dagestan State Medical University, 1 Lenin St, Makhachkala, Dagestan, 367008, Russia

    U. G. Gamzaeva

Authors
  1. Kh. A. Mirzaeva
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  2. U. G. Gamzaeva
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Correspondence to U. G. Gamzaeva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 9, pp. 61 – 64, September, 2018.

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Mirzaeva, K.A., Gamzaeva, U.G. Development of a Quantitative Spectrophotometric Determination Method for Papaverine in Medicinal Preparations. Pharm Chem J 52, 808–811 (2018). https://doi.org/10.1007/s11094-018-1905-3

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  • DOI: https://doi.org/10.1007/s11094-018-1905-3

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