A capillary electrophoresis technique for quantitative determination of phenibut in microcapsules was developed and validated. Rather high efficiencies (~200,000 theoretical plates) and the required resolution (Rs ≥ 1.5) were attained using sodium tetraborate decahydrate solution (10 mM) at pH 9.2 as the supporting electrolyte. Validation of the technique showed that it was specific and complied with requirements of the SP XIIIth Ed. with respect to analytical range and linearity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 9, pp. 56 – 60, September, 2018.
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Polkovnikova, Y.A., Koryanova, K.N., Slivkin, A.I. et al. Development and Validation of a Quantitative Determination Technique for Phenibut in Microcapsules. Pharm Chem J 52, 803–807 (2018). https://doi.org/10.1007/s11094-018-1904-4
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DOI: https://doi.org/10.1007/s11094-018-1904-4