Skip to main content
SpringerLink
Log in

Influence of Various Disintegrants on the Quality of Microcrystalline Cellulose Tablets

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

The effects of the superdisintegrants sodium starch glycolate, croscarmellose sodium, polacrilin potassium Kyron T-314, and Amberlite IRP 88 on the quality parameters of placebo tablets prepared from microcrystalline cellulose were studied. Sodium starch glycolate was most effective with croscarmellose sodium and Amberlite IRP 88 slightly less. All studied disintegrants gave dosage forms of pharmacopoeial quality. The effects of disintegrant concentration and particle type on tablet hardness were determined. The dosage form hardness increased with increasing disintegrant content for croscarmellose sodium with fibrous particles and decreased for sodium starch glycolate and polacrilin potassium with round and irregularly shaped particles. The tablets were harder if polacrilin potassium was added to the formulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.

Similar content being viewed by others

References

  1. T. Khess and A. Morozov, Farm. Otrasl’, 42(1), 72 – 74 (2014).

    Google Scholar 

  2. R. C. Rowe, P. J. Sheskey, and M. E. Quinn (eds.), Handbook of Pharmaceutical Excipients, 6th Ed., PhP, London, Chicago (2009), pp. 666 – 663.

  3. R. C. Rowe, P. J. Sheskey, and M. E. Quinn (eds.), Handbook of Pharmaceutical Excipients, 6th Ed., PhP, London, Chicago (2009), pp. 206 – 209.

  4. Corel Pharma Chem, Kyron™ T-314; URL: http: //www.corelpharmachem.com / kyron t314.htm

  5. AmberliteTM IRP 88 Pharmaceutical Grade Cation Exchange Resin (Polacrilin Potassium NF), 6 pp (2006).

  6. R. C. Rowe, P. J. Sheskey, and M. E. Quinn (eds.), Handbook of Pharmaceutical Excipients, 6th Ed., PhP, London, Chicago (2009), pp. 504 – 506.

  7. R. C. Rowe, P. J. Sheskey, and M. E. Quinn (eds.), Handbook of Pharmaceutical Excipients, 6th Ed., PhP, London, Chicago (2009), pp. 134 – 135.

  8. R. C. Rowe, P. J. Sheskey, and M. E. Quinn (eds.), Handbook of Pharmaceutical Excipients, 6th Ed., PhP, London, Chicago (2009), pp. 404 – 407.

  9. Encyclopedia of MPlast.by Polymers [in Russian], https: //mplast.by / encyklopedia / zavisimost-mehanicheskih-svoystvpolimerov-ot-nekotoryih-vneshnih-faktorov / (accessed Feb. 4, 2018).

Download references

Author information

Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russia

    N. B. Demina, N. V. Bobkova, E. A. Solodun, M. N. Anurova, E. O. Bakhrushina & I. I. Krasnyuk

Authors
  1. N. B. Demina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. V. Bobkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. A. Solodun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. N. Anurova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. O. Bakhrushina
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. I. I. Krasnyuk
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. B. Demina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 9, pp. 32 – 36, September, 2018.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Demina, N.B., Bobkova, N.V., Solodun, E.A. et al. Influence of Various Disintegrants on the Quality of Microcrystalline Cellulose Tablets. Pharm Chem J 52, 781–785 (2018). https://doi.org/10.1007/s11094-018-1899-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-018-1899-x

Keywords

Search

Navigation