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Automated Synthesis of [18F]Fluoromethylcholine for Positron-Emission Tomography Imaging

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

Automated technology for synthesizing [18F]fluoromethylcholine, a radiopharmaceutical for diagnostic positron-emission-tomography tumor imaging, was developed. A TRACERlab FXFN synthesis module (GE Healthcare) used the combined technology of on-line alkylation and solid-phase extraction. The synthesis module was modified to allow operation at various He flow rates in critical process steps. The radiochemical yield of [18F]fluoromethylcholine was >10%, which was sufficient to produce several clinical doses. The quality control parameters of the produced [18F]fluoromethylcholine met the requirements of the RF Pharmacopoeia.

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Acknowledgments

We thank staff of the PET center at Kazan Republic Oncological Dispensary T. N. Svetlakova, G. L. Kashapova, I. V. Bezchetvertnaya, and L. A. Smirnov for assistance with testing the synthesis technology. The work was financially supported by GE Healthcare, Russia.

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Authors and Affiliations

  1. N. P. Bekhtereva Institute of Human Brain, Russian Academy of Sciences, St. Petersburg, 197376, Russia

    O. S. Fedorova & R. N. Krasikova

  2. St. Petersburg State University, St. Petersburg, 199034, Russia

    O. S. Fedorova & R. N. Krasikova

  3. GE Healthcare Co., Moscow, 123317, Russia

    F. P. Vaitekhovich

Authors
  1. O. S. Fedorova
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  2. F. P. Vaitekhovich
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  3. R. N. Krasikova
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Correspondence to O. S. Fedorova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 8, pp. 41 – 45, August, 2018.

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Fedorova, O.S., Vaitekhovich, F.P. & Krasikova, R.N. Automated Synthesis of [18F]Fluoromethylcholine for Positron-Emission Tomography Imaging. Pharm Chem J 52, 730–734 (2018). https://doi.org/10.1007/s11094-018-1889-z

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  • DOI: https://doi.org/10.1007/s11094-018-1889-z

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