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Mechanical and Physical-Technological Properties of Gelatin Ribbon in the Manufacture of Soft Gelatin Capsules

Pharmaceutical Chemistry Journal volume 52, pages 644–647 (2018)Cite this article

The mechanical properties of gelatin ribbon and the rheology of bulk gelatin in the manufacture of soft gelatin capsules were studied. The results provide evidence that retention of the strength and elasticity of capsule casings during the manufacturing process and storage requires Young’s modulus of the gelatin ribbon to be in the range 35 – 50 MPa, the elongation at breaking being 210 – 240% and the tensile strength being 8 – 9 MPa. The studies also showed that regenerated gelatin stock loses its structural-mechanical properties, particularly its strength and plasticity, which can lead to failure of gelatin capsules during storage and drying.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Perm, Russia

    E. I. Molokhova & E. I. Ponomareva

  2. Institute of Continuous Medium Mechanics, Urals Department, Russian Academy of Sciences, Perm, Russia

    A. A. Adamov

  3. State Science Research Institute of Nutrition, Ministry of Energy and Industry of the Republic of Tajikistan, Dushanbe, Tajikistan

    A. K. Kholov

Authors
  1. E. I. Molokhova
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  2. E. I. Ponomareva
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  3. A. A. Adamov
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  4. A. K. Kholov
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Corresponding author

Correspondence to E. I. Ponomareva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 7, pp. 46 – 49, July, 2018.

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Molokhova, E.I., Ponomareva, E.I., Adamov, A.A. et al. Mechanical and Physical-Technological Properties of Gelatin Ribbon in the Manufacture of Soft Gelatin Capsules. Pharm Chem J 52, 644–647 (2018). https://doi.org/10.1007/s11094-018-1875-5

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  • DOI: https://doi.org/10.1007/s11094-018-1875-5

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