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Synthesis and Biological Activity of 4-ARYL-2-[(2-OXO-1,2-Diphenylethylidene)-Hydrazinyl]-4-Oxobut-2-Enoic-Acid Amides

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Pharmaceutical Chemistry Journal Aims and scope

4-Aryl-2-[(2-oxo-1,2-diphenylethylidene)hydrazinyl]-4-oxobut-2-enoic-acid amides were produced via decyclization of 3-[(2-oxo-1,2-diphenylethylidene)hydrazono]-5-arylfuran-2(3H)-ones by the corresponding amines and via reaction of 4-aryl-2-hydroxy-4-oxobut-2-enoic-acid hetarylamides with 2-hydrazono-1,2-diphenylethanone. Their analgesic and antibacterial activities were studied. Compounds with low toxicities and activities comparable to and exceeding those of reference drugs were discovered.

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Acknowledgments

The work was financially supported by the Ministry of Education of Perm Krai (Project MIG) and RFBR Grant 13-03-96016.

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Authors and Affiliations

  1. Perm State National Research University, 15 Bukireva, Perm, 614036, Russia

    R. A. Bykov, S. Yu. Balandina, O. A. Komarova, R. R. Makhmudov, F. V. Sobin & A. E. Rubtsov

  2. D. N. Pryanishnikov Perm State Agricultural Academy, 53 Petropavlovskaya, Perm, 614990, Russia

    N. N. Trapeznikova

  3. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, 46 Krupskoi, Perm, 614000, Russia

    N. A. Pulina

Authors
  1. R. A. Bykov
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  2. N. N. Trapeznikova
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  3. S. Yu. Balandina
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  4. O. A. Komarova
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  5. R. R. Makhmudov
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  6. N. A. Pulina
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  7. F. V. Sobin
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  8. A. E. Rubtsov
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Corresponding author

Correspondence to A. E. Rubtsov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 5, pp. 33 – 36, May, 2018.

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Bykov, R.A., Trapeznikova, N.N., Balandina, S.Y. et al. Synthesis and Biological Activity of 4-ARYL-2-[(2-OXO-1,2-Diphenylethylidene)-Hydrazinyl]-4-Oxobut-2-Enoic-Acid Amides. Pharm Chem J 52, 415–418 (2018). https://doi.org/10.1007/s11094-018-1833-2

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  • DOI: https://doi.org/10.1007/s11094-018-1833-2

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