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Optimization of Culture Conditions for the Production of Lovastatin by Aspergillus Terreus in Submerged Fermentation

The production of lovastatin by Aspergillus terreus PU-PCSIR-1 was studied using submerged fermentation technique. Effects of pH, incubation temperature, incubation time, and the media components on the production of lovastatin were investigated. Maximum lovastatin yield (198.90 mg/L) was achieved after 14 days of incubation at temperature 28°C and pH 7.4. Peptonized milk, linoleic acid, glucose, yeast extract, and trace elements had a positive impact on the production of lovastatin by A. terreus.

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Azeem, M., Saleem, Y., Hussain, Z. et al. Optimization of Culture Conditions for the Production of Lovastatin by Aspergillus Terreus in Submerged Fermentation. Pharm Chem J 52, 284–289 (2018). https://doi.org/10.1007/s11094-018-1807-4

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  • DOI: https://doi.org/10.1007/s11094-018-1807-4

Keywords

  • cholesterol
  • high performance liquid chromatography (HPLC)
  • lovastatin
  • submerged fermentation, Aspergillus terreus