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Pharmaceutical Chemistry Journal

, Volume 52, Issue 3, pp 284–289 | Cite as

Optimization of Culture Conditions for the Production of Lovastatin by Aspergillus Terreus in Submerged Fermentation

  • M. Azeem
  • Y. Saleem
  • Z. Hussain
  • S. Zahoor
  • M. M. Javed
Article

The production of lovastatin by Aspergillus terreus PU-PCSIR-1 was studied using submerged fermentation technique. Effects of pH, incubation temperature, incubation time, and the media components on the production of lovastatin were investigated. Maximum lovastatin yield (198.90 mg/L) was achieved after 14 days of incubation at temperature 28°C and pH 7.4. Peptonized milk, linoleic acid, glucose, yeast extract, and trace elements had a positive impact on the production of lovastatin by A. terreus.

Keywords

cholesterol high performance liquid chromatography (HPLC) lovastatin submerged fermentation, Aspergillus terreus 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • M. Azeem
    • 1
    • 2
  • Y. Saleem
    • 2
  • Z. Hussain
    • 1
  • S. Zahoor
    • 3
  • M. M. Javed
    • 1
  1. 1.Institute of Industrial BiotechnologyGovernment College UniversityLahorePakistan
  2. 2.Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial ResearchLahorePakistan
  3. 3.Department of BiotechnologyVirtual University of PakistanLahorePakistan

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