Release Testing of Selected Drugs from Surface Magnetic Nanoparticles and Their Diffusion Through a Membrane
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In this study, magnetic nanoparticles were functionalized with dextran and immobilized ibuprofen, diclofenac, and dopamine in order to investigate the diffusion of drugs through a dialysis membrane under biological conditions such as a temperature of 37.0°C and pH 7.4. The concentration of released drugs was measured both inside the membrane and upon release into solution using spectrofluorimetric and spectrophotometric methods. The mechanism of drug release from the carrier was analyzed in terms of the Korsmeyer – Peppas model. The results show that differences in the mechanism of drug release depend on the time-diffusion process and the type of drug used. In addition, the atomic force microscopy and confocal microscopy methods were used to investigate the interaction between bacterial cells and functionalized nanoparticles.
Keywordsmagnetic nanoparticles drug release diffusion membrane nonsteroidal anti-inflammatory drugs NSAIDs, dopamine, Korsmeyer – Peppas model, Lactobacillus bacteria
The authors thank Dr. B. Zapotoczny for fruitful discussion of suggestions concerning drug release investigations.