Skip to main content

Approaches to Pharmaceutical Analysis of an Innovative Liposomal Preparation for Treating Hepatitis C

The composite Y14/siUTR, a complex consisting of cationic lipopeptide Y14 as an excipient and pharmaceutical substance of small interfering RNAtargeted against the UTR region of hepatitis C virus (siUTR), was investigated. The composite was intended to inhibit the hepatitis C virus replication cycle. The present work was aimed at developing pharmaceutical analytical methods for the components of this composite using HPLC-UV and UV spectroscopy.

This is a preview of subscription content, access via your institution.

References

  1. I. P. Shilovskii, M. S. Sundukova, A. R. Gaisina, et al., Eksp. Klin. Farmakol., 79(4), 35 – 44 (2016).

    CAS  PubMed  Google Scholar 

  2. M. A. Zaretskaia, I. P. Shilovskiy, A. A. Nikonova, et al., Allergy, 72, Issue S103, No. 0427, 306 (2017).

  3. H. Brody, L. Gravitz, J. Schlutter, et al., Nature, Nature Publ. Group, London (2011), S1-S21.

  4. J. Vermehren, B. Schlosser, D. Domke, et al., PLoS One, No. 7, e41206 (2012).

  5. J. W. Schoggins and C. M. Rice, Curr. Top. Microbiol. Immunol., No. 369, 219 – 242 (2013).

  6. T. K. Scheel and C. M. Rice, Nat. Med., No. 19, 837 – 849 (2013).

  7. A. N. Mironov (ed.), Guide for Drug Review [in Russian], Vol. 1, Moscow (2013).

Download references

Author information

Authors and Affiliations

Authors

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 59 – 61, March, 2018.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Smirnov, V.V., Krasnykh, L.M., Shilovskii, I.P. et al. Approaches to Pharmaceutical Analysis of an Innovative Liposomal Preparation for Treating Hepatitis C. Pharm Chem J 52, 254–256 (2018). https://doi.org/10.1007/s11094-018-1802-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-018-1802-9

Keywords

  • hepatitis C
  • liposomes
  • RNA interference
  • HPLC-UV
  • spectrophotometry