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Pharmaceutical Chemistry Journal

, Volume 52, Issue 3, pp 254–256 | Cite as

Approaches to Pharmaceutical Analysis of an Innovative Liposomal Preparation for Treating Hepatitis C

  • V. V. Smirnov
  • L. M. Krasnykh
  • I. P. Shilovskii
  • A. P. Ryzhenkova
  • M. R. Khaitov
  • V. N. Drozdov
Article

The composite Y14/siUTR, a complex consisting of cationic lipopeptide Y14 as an excipient and pharmaceutical substance of small interfering RNAtargeted against the UTR region of hepatitis C virus (siUTR), was investigated. The composite was intended to inhibit the hepatitis C virus replication cycle. The present work was aimed at developing pharmaceutical analytical methods for the components of this composite using HPLC-UV and UV spectroscopy.

Keywords

hepatitis C liposomes RNA interference HPLC-UV spectrophotometry 

References

  1. 1.
    I. P. Shilovskii, M. S. Sundukova, A. R. Gaisina, et al., Eksp. Klin. Farmakol., 79(4), 35 – 44 (2016).PubMedGoogle Scholar
  2. 2.
    M. A. Zaretskaia, I. P. Shilovskiy, A. A. Nikonova, et al., Allergy, 72, Issue S103, No. 0427, 306 (2017).Google Scholar
  3. 3.
    H. Brody, L. Gravitz, J. Schlutter, et al., Nature, Nature Publ. Group, London (2011), S1-S21.Google Scholar
  4. 4.
    J. Vermehren, B. Schlosser, D. Domke, et al., PLoS One, No. 7, e41206 (2012).Google Scholar
  5. 5.
    J. W. Schoggins and C. M. Rice, Curr. Top. Microbiol. Immunol., No. 369, 219 – 242 (2013).Google Scholar
  6. 6.
    T. K. Scheel and C. M. Rice, Nat. Med., No. 19, 837 – 849 (2013).Google Scholar
  7. 7.
    A. N. Mironov (ed.), Guide for Drug Review [in Russian], Vol. 1, Moscow (2013).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • V. V. Smirnov
    • 1
    • 2
    • 3
  • L. M. Krasnykh
    • 1
  • I. P. Shilovskii
    • 2
  • A. P. Ryzhenkova
    • 3
  • M. R. Khaitov
    • 2
  • V. N. Drozdov
    • 3
  1. 1.Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian FederationMoscowRussia
  2. 2.Institute of Immunology, Federal Medico-Biological Agency of the Russian FederationMoscowRussia
  3. 3.I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)MoscowRussia

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